Stem Cell-Based Therapies in Chagasic Cardiomyopathy

Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transpla...

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Detalles Bibliográficos
Autores principales: Campos de Carvalho, Antonio Carlos, Bastos Carvalho, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486210/
https://www.ncbi.nlm.nih.gov/pubmed/26161401
http://dx.doi.org/10.1155/2015/436314
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author Campos de Carvalho, Antonio Carlos
Bastos Carvalho, Adriana
author_facet Campos de Carvalho, Antonio Carlos
Bastos Carvalho, Adriana
author_sort Campos de Carvalho, Antonio Carlos
collection PubMed
description Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been investigated in preclinical and clinical studies. In this paper we review the main findings of such studies and discuss future directions for stem cell-based therapies in chronic chagasic cardiomyopathy.
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spelling pubmed-44862102015-07-09 Stem Cell-Based Therapies in Chagasic Cardiomyopathy Campos de Carvalho, Antonio Carlos Bastos Carvalho, Adriana Biomed Res Int Review Article Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been investigated in preclinical and clinical studies. In this paper we review the main findings of such studies and discuss future directions for stem cell-based therapies in chronic chagasic cardiomyopathy. Hindawi Publishing Corporation 2015 2015-06-15 /pmc/articles/PMC4486210/ /pubmed/26161401 http://dx.doi.org/10.1155/2015/436314 Text en Copyright © 2015 A. C. Campos de Carvalho and A. Bastos Carvalho. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Campos de Carvalho, Antonio Carlos
Bastos Carvalho, Adriana
Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_full Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_fullStr Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_full_unstemmed Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_short Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_sort stem cell-based therapies in chagasic cardiomyopathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486210/
https://www.ncbi.nlm.nih.gov/pubmed/26161401
http://dx.doi.org/10.1155/2015/436314
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