Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation

Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing...

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Detalles Bibliográficos
Autores principales: Hill, Joshua A, Boeckh, Michael, Leisenring, Wendy M, Xie, Hu, Adler, Amanda L, Huang, Meei-Li, Fann, Jesse R, Delaney, Colleen, Zerr, Danielle M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486349/
https://www.ncbi.nlm.nih.gov/pubmed/26121112
http://dx.doi.org/10.1038/bmt.2015.154
Descripción
Sumario:Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing for HHV-6 and thrice-weekly delirium assessment until day 84. There was a quantitative association between HHV-6 reactivation and delirium in univariable (odds ratio, 2.88; 95% confidence interval [CI], 0.97–8.59) and bivariable models. In addition, intensified prophylaxis with high-dose valacyclovir mitigated HHV-6 reactivation (adjusted hazard ratio, 0.39; 95% CI, 0.14–1.08). Larger trials are needed to explore the utility of HHV-6 prophylaxis after CBT.

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