Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation

Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing...

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Autores principales: Hill, Joshua A, Boeckh, Michael, Leisenring, Wendy M, Xie, Hu, Adler, Amanda L, Huang, Meei-Li, Fann, Jesse R, Delaney, Colleen, Zerr, Danielle M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486349/
https://www.ncbi.nlm.nih.gov/pubmed/26121112
http://dx.doi.org/10.1038/bmt.2015.154
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author Hill, Joshua A
Boeckh, Michael
Leisenring, Wendy M
Xie, Hu
Adler, Amanda L
Huang, Meei-Li
Fann, Jesse R
Delaney, Colleen
Zerr, Danielle M
author_facet Hill, Joshua A
Boeckh, Michael
Leisenring, Wendy M
Xie, Hu
Adler, Amanda L
Huang, Meei-Li
Fann, Jesse R
Delaney, Colleen
Zerr, Danielle M
author_sort Hill, Joshua A
collection PubMed
description Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing for HHV-6 and thrice-weekly delirium assessment until day 84. There was a quantitative association between HHV-6 reactivation and delirium in univariable (odds ratio, 2.88; 95% confidence interval [CI], 0.97–8.59) and bivariable models. In addition, intensified prophylaxis with high-dose valacyclovir mitigated HHV-6 reactivation (adjusted hazard ratio, 0.39; 95% CI, 0.14–1.08). Larger trials are needed to explore the utility of HHV-6 prophylaxis after CBT.
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spelling pubmed-44863492016-04-01 Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation Hill, Joshua A Boeckh, Michael Leisenring, Wendy M Xie, Hu Adler, Amanda L Huang, Meei-Li Fann, Jesse R Delaney, Colleen Zerr, Danielle M Bone Marrow Transplant Article Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing for HHV-6 and thrice-weekly delirium assessment until day 84. There was a quantitative association between HHV-6 reactivation and delirium in univariable (odds ratio, 2.88; 95% confidence interval [CI], 0.97–8.59) and bivariable models. In addition, intensified prophylaxis with high-dose valacyclovir mitigated HHV-6 reactivation (adjusted hazard ratio, 0.39; 95% CI, 0.14–1.08). Larger trials are needed to explore the utility of HHV-6 prophylaxis after CBT. 2015-06-29 2015-10 /pmc/articles/PMC4486349/ /pubmed/26121112 http://dx.doi.org/10.1038/bmt.2015.154 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hill, Joshua A
Boeckh, Michael
Leisenring, Wendy M
Xie, Hu
Adler, Amanda L
Huang, Meei-Li
Fann, Jesse R
Delaney, Colleen
Zerr, Danielle M
Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation
title Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation
title_full Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation
title_fullStr Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation
title_full_unstemmed Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation
title_short Human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation
title_sort human herpesvirus 6 reactivation and delirium are frequent and associated events after cord blood transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486349/
https://www.ncbi.nlm.nih.gov/pubmed/26121112
http://dx.doi.org/10.1038/bmt.2015.154
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