Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye

BACKGROUND: The membrane attack complex (MAC) is a key player in the pathogenesis of age-related macular degeneration (AMD) and is a putative activator of the NLRP3 inflammasome. Amyloid beta (Aβ), a component of drusen deposits, has also been implicated in inflammasome activation by our work and th...

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Detalles Bibliográficos
Autores principales: Zhao, Tom, Gao, Jiangyuan, Van, Jenifer, To, Eleanor, Wang, Aikun, Cao, Sijia, Cui, Jing Z., Guo, Jian-Ping, Lee, Moonhee, McGeer, Patrick L., Matsubara, Joanne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486438/
https://www.ncbi.nlm.nih.gov/pubmed/26104676
http://dx.doi.org/10.1186/s12974-015-0337-1

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