BRAF gene: From human cancers to developmental syndromes

The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade i...

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Autores principales: Hussain, Muhammad Ramzan Manwar, Baig, Mukhtiar, Mohamoud, Hussein Sheik Ali, Ulhaq, Zaheer, Hoessli, Daniel C., Khogeer, Ghaidaa Siraj, Al-Sayed, Ranem Radwan, Al-Aama, Jumana Yousuf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486731/
https://www.ncbi.nlm.nih.gov/pubmed/26150740
http://dx.doi.org/10.1016/j.sjbs.2014.10.002
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author Hussain, Muhammad Ramzan Manwar
Baig, Mukhtiar
Mohamoud, Hussein Sheik Ali
Ulhaq, Zaheer
Hoessli, Daniel C.
Khogeer, Ghaidaa Siraj
Al-Sayed, Ranem Radwan
Al-Aama, Jumana Yousuf
author_facet Hussain, Muhammad Ramzan Manwar
Baig, Mukhtiar
Mohamoud, Hussein Sheik Ali
Ulhaq, Zaheer
Hoessli, Daniel C.
Khogeer, Ghaidaa Siraj
Al-Sayed, Ranem Radwan
Al-Aama, Jumana Yousuf
author_sort Hussain, Muhammad Ramzan Manwar
collection PubMed
description The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes—Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.
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spelling pubmed-44867312015-07-06 BRAF gene: From human cancers to developmental syndromes Hussain, Muhammad Ramzan Manwar Baig, Mukhtiar Mohamoud, Hussein Sheik Ali Ulhaq, Zaheer Hoessli, Daniel C. Khogeer, Ghaidaa Siraj Al-Sayed, Ranem Radwan Al-Aama, Jumana Yousuf Saudi J Biol Sci Review The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes—Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome. Elsevier 2015-07 2014-10-23 /pmc/articles/PMC4486731/ /pubmed/26150740 http://dx.doi.org/10.1016/j.sjbs.2014.10.002 Text en © 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Review
Hussain, Muhammad Ramzan Manwar
Baig, Mukhtiar
Mohamoud, Hussein Sheik Ali
Ulhaq, Zaheer
Hoessli, Daniel C.
Khogeer, Ghaidaa Siraj
Al-Sayed, Ranem Radwan
Al-Aama, Jumana Yousuf
BRAF gene: From human cancers to developmental syndromes
title BRAF gene: From human cancers to developmental syndromes
title_full BRAF gene: From human cancers to developmental syndromes
title_fullStr BRAF gene: From human cancers to developmental syndromes
title_full_unstemmed BRAF gene: From human cancers to developmental syndromes
title_short BRAF gene: From human cancers to developmental syndromes
title_sort braf gene: from human cancers to developmental syndromes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486731/
https://www.ncbi.nlm.nih.gov/pubmed/26150740
http://dx.doi.org/10.1016/j.sjbs.2014.10.002
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