Cargando…

BRAF gene: From human cancers to developmental syndromes

The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hussain, Muhammad Ramzan Manwar, Baig, Mukhtiar, Mohamoud, Hussein Sheik Ali, Ulhaq, Zaheer, Hoessli, Daniel C., Khogeer, Ghaidaa Siraj, Al-Sayed, Ranem Radwan, Al-Aama, Jumana Yousuf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486731/ https://www.ncbi.nlm.nih.gov/pubmed/26150740 http://dx.doi.org/10.1016/j.sjbs.2014.10.002

Ejemplares similares

First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene
por: Ali Mohamoud, Hussein Sheikh, et al.
Publicado: (2014)

N-acetylgalactosaminyltransferases in cancer
por: Hussain, Muhammad Ramzan Manwar, et al.
Publicado: (2016)

From Genes to Health – Challenges and Opportunities
por: Manwar Hussain, Muhammad Ramzan, et al.
Publicado: (2014)

Charge and Polarity Preferences for N-Glycosylation: A Genome-Wide In Silico Study and Its Implications Regarding Constitutive Proliferation and Adhesion of Carcinoma Cells
por: Manwar Hussain, Muhammad Ramzan, et al.
Publicado: (2018)

Truncating mutation in intracellular phospholipase A(1) gene (DDHD2) in hereditary spastic paraplegia with intellectual disability (SPG54)
por: Alrayes, Nuha, et al.
Publicado: (2015)

Whole-exome sequencing reveals a recurrent mutation in the cathepsin C gene that causes Papillon–Lefevre syndrome in a Saudi family
por: Alkhiary, Yaser Mohammad, et al.
Publicado: (2016)

A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features
por: Mohamoud, Hussein Sheikh, et al.
Publicado: (2018)

A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities
por: Jelani, Musharraf, et al.
Publicado: (2019)

Specialty Grand Challenge – Genetic Disorders
por: Al-Aama, Jumana Y.
Publicado: (2013)

Arabic Captioning for Images of Clothing Using Deep Learning
por: Al-Malki, Rasha Saleh, et al.
Publicado: (2023)

Genome-Wide Association Study-Guided Exome Rare Variant Burden Analysis Identifies IL1R1 and CD3E as Potential Autoimmunity Risk Genes for Celiac Disease
por: Mansour, Haifa, et al.
Publicado: (2022)

Deletion mutation in BSCL2 gene underlies congenital generalized lipodystrophy in a Pakistani family
por: Rahman, Obaid Ur, et al.
Publicado: (2013)

Exome Analysis Identifies a Novel Compound Heterozygous Alteration in TGM1 Gene Leading to Lamellar Ichthyosis in a Child From Saudi Arabia: Case Presentation
por: Alallasi, Sami Raja, et al.
Publicado: (2019)

Congenital Long QT Syndrome: An Update and Present Perspective in Saudi Arabia
por: Bhuiyan, Zahurul A., et al.
Publicado: (2013)

Manuscript Writing and Publication Workshop: An Invoking Pilot Study on Enhancing Cognitive Research Capabilities in Health Sciences Institutes of Pakistan
por: Hussain, Mehwish, et al.
Publicado: (2020)

Effect of the Surface Functionalization of Graphene and MWCNT on the Thermodynamic, Mechanical and Electrical Properties of the Graphene/MWCNT-PVDF Nanocomposites
por: Al-Harthi, Mamdouh A., et al.
Publicado: (2022)

Effect of Fabrication Method on the Thermo Mechanical and Electrical Properties of Graphene Doped PVDF Nanocomposites
por: Al-Harthi, Mamdouh A., et al.
Publicado: (2022)

Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2020)

Editorial: Targeting Phosphorylation and Glycosylation of Membrane-Bound Oncogenic Drivers, Receptors and Adhesion Molecules to Control Constitutive Proliferation of Human Carcinoma Cells
por: Hussain, Muhammad R. M., et al.
Publicado: (2018)

A case of large deep fibrolipoma in the left subclavicular region that compromised the branchial plexus and thoracic duct: A case report
por: Hussain, Jumana, et al.
Publicado: (2018)

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma
por: Siraj, Abdul K, et al.
Publicado: (2014)

Correspondence
por: Baig, Mukhtiar
Publicado: (2019)

Association of serum osteoprotegerin with severity of chronic liver disease in female patients: A potential biomarker
por: Tariq, Saba, et al.
Publicado: (2020)

Health Impact of Fasting in Saudi Arabia during Ramadan: Association with Disturbed Circadian Rhythm and Metabolic and Sleeping Patterns
por: Ajabnoor, Ghada M., et al.
Publicado: (2014)

A Novel Homozygous Frameshift Mutation in CCN6 Causing Progressive Pseudorheumatoid Dysplasia (PPRD) in a Consanguineous Yemeni Family
por: Gaboon, Nagwa E. A., et al.
Publicado: (2019)

Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City
por: Alzahrani, Fatma, et al.
Publicado: (2021)

Exploring celiac disease candidate pathways by global gene expression profiling and gene network cluster analysis
por: Banaganapalli, Babajan, et al.
Publicado: (2020)

TagSNP approach for HLA risk allele genotyping of Saudi celiac disease patients: effectiveness and pitfalls
por: Baaqeel, Reham H., et al.
Publicado: (2021)

Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells
por: Jeong, Minjin, et al.
Publicado: (2018)

Coronavirus Disease 2019 Pandemic Effects on Overseas Pakistanis Particularly Residing in China, Saudi Arabia and United Kingdom
por: Ahmad, Tauseef, et al.
Publicado: (2022)

BRAF mutations in thyroid tumors from an ethnically diverse group
por: Schulten, Hans-Juergen, et al.
Publicado: (2012)

Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer
por: Siraj, Abdul Khalid, et al.
Publicado: (2022)

Assessment of quality of life (QoL) in breast cancer patients by using EORTC QLQ-C30 and BR-23 questionnaires: A tertiary care center survey in the western region of Saudi Arabia
por: Imran, Muhammad, et al.
Publicado: (2019)

Estradiol progesterone ratio on ovulation induction day: a determinant of successful pregnancy outcome after intra cytoplasmic sperm injection
por: Rehman, Rehana, et al.
Publicado: (2014)

Seroprevalence of hepatitis E virus infection in pregnant women: a systematic review and meta-analysis
por: Ahmad, Tauseef, et al.
Publicado: (2020)

Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals
por: Al-malky, Hamdan S., et al.
Publicado: (2019)

Novel MYO1D Missense Variant Identified Through Whole Exome Sequencing and Computational Biology Analysis Expands the Spectrum of Causal Genes of Laterality Defects
por: Alsafwani, Rabab Said, et al.
Publicado: (2021)

Effect of BRAF mutational status on expression profiles in conventional papillary thyroid carcinomas
por: Schulten, Hans-Juergen, et al.
Publicado: (2015)

Whole exome sequencing of a Saudi family and systems biology analysis identifies CPED1 as a putative causative gene to Celiac Disease
por: Bokhari, Hifaa A., et al.
Publicado: (2020)

Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors
por: Ajabnoor, Ghada M. A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f0aj2ffbf0se3uob6en1dg7bem