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Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()()

OBJECTIVES: This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS: Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, g...

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Autores principales: Jafari-Khouzani, Kourosh, Emblem, Kyrre E., Kalpathy-Cramer, Jayashree, Bjørnerud, Atle, Vangel, Mark G., Gerstner, Elizabeth R., Schmainda, Kathleen M., Paynabar, Kamran, Wu, Ona, Wen, Patrick Y., Batchelor, Tracy, Rosen, Bruce, Stufflebeam, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486737/
https://www.ncbi.nlm.nih.gov/pubmed/26055170
http://dx.doi.org/10.1016/j.tranon.2015.03.002
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author Jafari-Khouzani, Kourosh
Emblem, Kyrre E.
Kalpathy-Cramer, Jayashree
Bjørnerud, Atle
Vangel, Mark G.
Gerstner, Elizabeth R.
Schmainda, Kathleen M.
Paynabar, Kamran
Wu, Ona
Wen, Patrick Y.
Batchelor, Tracy
Rosen, Bruce
Stufflebeam, Steven M.
author_facet Jafari-Khouzani, Kourosh
Emblem, Kyrre E.
Kalpathy-Cramer, Jayashree
Bjørnerud, Atle
Vangel, Mark G.
Gerstner, Elizabeth R.
Schmainda, Kathleen M.
Paynabar, Kamran
Wu, Ona
Wen, Patrick Y.
Batchelor, Tracy
Rosen, Bruce
Stufflebeam, Steven M.
author_sort Jafari-Khouzani, Kourosh
collection PubMed
description OBJECTIVES: This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS: Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-echo DSC-MRI protocol, the patients were scanned twice 1 to 5 days apart. Perfusion maps including cerebral blood volume (CBV) and cerebral blood flow (CBF) were generated using two contrast agent leakage correction methods, along with testing normalization to reference tissue, and application of arterial input function (AIF). Repeatability of CBV and CBF within tumor regions and healthy tissues, identified by structural images, was assessed with intra-class correlation coefficients (ICCs) and repeatability coefficients (RCs). Coefficients of variation (CVs) were reported for selected methods. RESULTS: CBV and CBF were highly repeatable within tumor with ICC values up to 0.97. However, both CBV and CBF showed lower ICCs for healthy cortical tissues (up to 0.83), healthy gray matter (up to 0.95), and healthy white matter (WM; up to 0.93). The values of CV ranged from 6% to 10% in tumor and 3% to 11% in healthy tissues. The values of RC relative to the mean value of measurement within healthy WM ranged from 22% to 42% in tumor and 7% to 43% in healthy tissues. These percentages show how much variation in perfusion parameter, relative to that in healthy WM, we expect to observe to consider it statistically significant. We also found that normalization improved repeatability, but AIF deconvolution did not. CONCLUSIONS: DSC-MRI is highly repeatable in high-grade glioma patients.
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spelling pubmed-44867372015-07-07 Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()() Jafari-Khouzani, Kourosh Emblem, Kyrre E. Kalpathy-Cramer, Jayashree Bjørnerud, Atle Vangel, Mark G. Gerstner, Elizabeth R. Schmainda, Kathleen M. Paynabar, Kamran Wu, Ona Wen, Patrick Y. Batchelor, Tracy Rosen, Bruce Stufflebeam, Steven M. Transl Oncol Article OBJECTIVES: This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS: Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-echo DSC-MRI protocol, the patients were scanned twice 1 to 5 days apart. Perfusion maps including cerebral blood volume (CBV) and cerebral blood flow (CBF) were generated using two contrast agent leakage correction methods, along with testing normalization to reference tissue, and application of arterial input function (AIF). Repeatability of CBV and CBF within tumor regions and healthy tissues, identified by structural images, was assessed with intra-class correlation coefficients (ICCs) and repeatability coefficients (RCs). Coefficients of variation (CVs) were reported for selected methods. RESULTS: CBV and CBF were highly repeatable within tumor with ICC values up to 0.97. However, both CBV and CBF showed lower ICCs for healthy cortical tissues (up to 0.83), healthy gray matter (up to 0.95), and healthy white matter (WM; up to 0.93). The values of CV ranged from 6% to 10% in tumor and 3% to 11% in healthy tissues. The values of RC relative to the mean value of measurement within healthy WM ranged from 22% to 42% in tumor and 7% to 43% in healthy tissues. These percentages show how much variation in perfusion parameter, relative to that in healthy WM, we expect to observe to consider it statistically significant. We also found that normalization improved repeatability, but AIF deconvolution did not. CONCLUSIONS: DSC-MRI is highly repeatable in high-grade glioma patients. Neoplasia Press 2015-06-05 /pmc/articles/PMC4486737/ /pubmed/26055170 http://dx.doi.org/10.1016/j.tranon.2015.03.002 Text en © 2015 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Jafari-Khouzani, Kourosh
Emblem, Kyrre E.
Kalpathy-Cramer, Jayashree
Bjørnerud, Atle
Vangel, Mark G.
Gerstner, Elizabeth R.
Schmainda, Kathleen M.
Paynabar, Kamran
Wu, Ona
Wen, Patrick Y.
Batchelor, Tracy
Rosen, Bruce
Stufflebeam, Steven M.
Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()()
title Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()()
title_full Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()()
title_fullStr Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()()
title_full_unstemmed Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()()
title_short Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients()()
title_sort repeatability of cerebral perfusion using dynamic susceptibility contrast mri in glioblastoma patients()()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486737/
https://www.ncbi.nlm.nih.gov/pubmed/26055170
http://dx.doi.org/10.1016/j.tranon.2015.03.002
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