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Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most stu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486754/ https://www.ncbi.nlm.nih.gov/pubmed/26161302 http://dx.doi.org/10.1155/2015/891020 |
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author | Okuyama Kishima, Marina de Oliveira, Carlos Eduardo Coral Banin-Hirata, Bruna Karina Losi-Guembarovski, Roberta Brajão de Oliveira, Karen Amarante, Marla Karine Watanabe, Maria Angelica Ehara |
author_facet | Okuyama Kishima, Marina de Oliveira, Carlos Eduardo Coral Banin-Hirata, Bruna Karina Losi-Guembarovski, Roberta Brajão de Oliveira, Karen Amarante, Marla Karine Watanabe, Maria Angelica Ehara |
author_sort | Okuyama Kishima, Marina |
collection | PubMed |
description | Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance. |
format | Online Article Text |
id | pubmed-4486754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44867542015-07-09 Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance Okuyama Kishima, Marina de Oliveira, Carlos Eduardo Coral Banin-Hirata, Bruna Karina Losi-Guembarovski, Roberta Brajão de Oliveira, Karen Amarante, Marla Karine Watanabe, Maria Angelica Ehara Anal Cell Pathol (Amst) Review Article Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance. Hindawi Publishing Corporation 2015 2015-06-16 /pmc/articles/PMC4486754/ /pubmed/26161302 http://dx.doi.org/10.1155/2015/891020 Text en Copyright © 2015 Marina Okuyama Kishima et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Okuyama Kishima, Marina de Oliveira, Carlos Eduardo Coral Banin-Hirata, Bruna Karina Losi-Guembarovski, Roberta Brajão de Oliveira, Karen Amarante, Marla Karine Watanabe, Maria Angelica Ehara Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
title | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
title_full | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
title_fullStr | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
title_full_unstemmed | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
title_short | Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance |
title_sort | immunohistochemical expression of cxcr4 on breast cancer and its clinical significance |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486754/ https://www.ncbi.nlm.nih.gov/pubmed/26161302 http://dx.doi.org/10.1155/2015/891020 |
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