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Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance

Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most stu...

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Autores principales: Okuyama Kishima, Marina, de Oliveira, Carlos Eduardo Coral, Banin-Hirata, Bruna Karina, Losi-Guembarovski, Roberta, Brajão de Oliveira, Karen, Amarante, Marla Karine, Watanabe, Maria Angelica Ehara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486754/
https://www.ncbi.nlm.nih.gov/pubmed/26161302
http://dx.doi.org/10.1155/2015/891020
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author Okuyama Kishima, Marina
de Oliveira, Carlos Eduardo Coral
Banin-Hirata, Bruna Karina
Losi-Guembarovski, Roberta
Brajão de Oliveira, Karen
Amarante, Marla Karine
Watanabe, Maria Angelica Ehara
author_facet Okuyama Kishima, Marina
de Oliveira, Carlos Eduardo Coral
Banin-Hirata, Bruna Karina
Losi-Guembarovski, Roberta
Brajão de Oliveira, Karen
Amarante, Marla Karine
Watanabe, Maria Angelica Ehara
author_sort Okuyama Kishima, Marina
collection PubMed
description Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance.
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spelling pubmed-44867542015-07-09 Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance Okuyama Kishima, Marina de Oliveira, Carlos Eduardo Coral Banin-Hirata, Bruna Karina Losi-Guembarovski, Roberta Brajão de Oliveira, Karen Amarante, Marla Karine Watanabe, Maria Angelica Ehara Anal Cell Pathol (Amst) Review Article Many tumor cells express chemokines and chemokine receptors, and, for this reason, these molecules can affect the tumor progression. It is known that breast cancer is a complex and heterogeneous neoplasia comprising distinct diseases, histological characteristics, and clinical outcomes. The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for breast cancer cell migration to other sites such as lung, bone, and lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 is being considered a prognostic marker in breast cancer. Within this context, this review summarizes established studies involving expression of CXCR4 on breast cancer, focusing on its clinical significance. Hindawi Publishing Corporation 2015 2015-06-16 /pmc/articles/PMC4486754/ /pubmed/26161302 http://dx.doi.org/10.1155/2015/891020 Text en Copyright © 2015 Marina Okuyama Kishima et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Okuyama Kishima, Marina
de Oliveira, Carlos Eduardo Coral
Banin-Hirata, Bruna Karina
Losi-Guembarovski, Roberta
Brajão de Oliveira, Karen
Amarante, Marla Karine
Watanabe, Maria Angelica Ehara
Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
title Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
title_full Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
title_fullStr Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
title_full_unstemmed Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
title_short Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance
title_sort immunohistochemical expression of cxcr4 on breast cancer and its clinical significance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486754/
https://www.ncbi.nlm.nih.gov/pubmed/26161302
http://dx.doi.org/10.1155/2015/891020
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