Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?

Now, it has been being accepted that reverse signaling through CD137 ligand (CD137L) plays an important role in vivo during hematopoiesis and in immune regulation. However, due to technical difficulty in dissecting both directional signaling events simultaneously in vivo, most biological activities...

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Detalles Bibliográficos
Autor principal: Kwon, Byungsuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486774/
https://www.ncbi.nlm.nih.gov/pubmed/26140043
http://dx.doi.org/10.4110/in.2015.15.3.121
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author Kwon, Byungsuk
author_facet Kwon, Byungsuk
author_sort Kwon, Byungsuk
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description Now, it has been being accepted that reverse signaling through CD137 ligand (CD137L) plays an important role in vivo during hematopoiesis and in immune regulation. However, due to technical difficulty in dissecting both directional signaling events simultaneously in vivo, most biological activities caused by CD137-CD137L interactions are considered as results from signaling events of the CD137 receptor. To make the story more complex, CD137(-/-) and CD137L(-/-) mice have increased or decreased immune responses in a context-dependent manner. In this Mini review, I will try to provide a plausible explanation for how CD137L signaling is controlled during immune responses.
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spelling pubmed-44867742015-07-02 Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses? Kwon, Byungsuk Immune Netw Review Article Now, it has been being accepted that reverse signaling through CD137 ligand (CD137L) plays an important role in vivo during hematopoiesis and in immune regulation. However, due to technical difficulty in dissecting both directional signaling events simultaneously in vivo, most biological activities caused by CD137-CD137L interactions are considered as results from signaling events of the CD137 receptor. To make the story more complex, CD137(-/-) and CD137L(-/-) mice have increased or decreased immune responses in a context-dependent manner. In this Mini review, I will try to provide a plausible explanation for how CD137L signaling is controlled during immune responses. The Korean Association of Immunologists 2015-06 2015-06-25 /pmc/articles/PMC4486774/ /pubmed/26140043 http://dx.doi.org/10.4110/in.2015.15.3.121 Text en Copyright © 2015 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kwon, Byungsuk
Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
title Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
title_full Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
title_fullStr Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
title_full_unstemmed Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
title_short Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
title_sort is cd137 ligand (cd137l) signaling a fine tuner of immune responses?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486774/
https://www.ncbi.nlm.nih.gov/pubmed/26140043
http://dx.doi.org/10.4110/in.2015.15.3.121
work_keys_str_mv AT kwonbyungsuk iscd137ligandcd137lsignalingafinetunerofimmuneresponses

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