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Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people
OBJECTIVES: The endothelial lipase gene (LIPG) is one of the important genes in the metabolism of high-density lipoprotein cholesterol (HDL-C) and may be involved in the pathogenesis of coronary artery disease (CAD). MATERIALS AND METHODS: To investigate the relationship between the common single nu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486941/ https://www.ncbi.nlm.nih.gov/pubmed/26124511 http://dx.doi.org/10.1136/bmjopen-2015-007621 |
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author | Xie, Liang Sun, Yan Tong, Yu Liu, Ying Deng, Ying |
author_facet | Xie, Liang Sun, Yan Tong, Yu Liu, Ying Deng, Ying |
author_sort | Xie, Liang |
collection | PubMed |
description | OBJECTIVES: The endothelial lipase gene (LIPG) is one of the important genes in the metabolism of high-density lipoprotein cholesterol (HDL-C) and may be involved in the pathogenesis of coronary artery disease (CAD). MATERIALS AND METHODS: To investigate the relationship between the common single nucleotide polymorphisms (SNPs) 584C/T (rs2000813) and −384A/C (rs3813082) in the LIPG gene and CAD, allele and genotype frequencies of the two SNPs were analysed in 287 Chinese patients with CAD and 367 controls by the high-resolution melting curve (HRM) method. RESULTS: For 584C/T, no significant difference in polymorphic distribution was observed between patients and controls. However, the frequencies of allele C (20.2% vs 15%, p=0.013, OR=1.437, 95% CI 1.078 to 1.915) at −384A/C were significantly increased in patients compared with controls. Haplotype analysis also showed that haplotype CT (12.37% vs 8.72%, p=0.035, OR=1.478, 95% CI 1.034 to 2.112) was significantly higher in patients compared with controls. CONCLUSIONS: These results suggested that the SNP −384A/C in the LIPG gene may be associated with risk for CAD and the LIPG gene may play a role in CAD in the Han Chinese. |
format | Online Article Text |
id | pubmed-4486941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44869412015-07-20 Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people Xie, Liang Sun, Yan Tong, Yu Liu, Ying Deng, Ying BMJ Open Genetics and Genomics OBJECTIVES: The endothelial lipase gene (LIPG) is one of the important genes in the metabolism of high-density lipoprotein cholesterol (HDL-C) and may be involved in the pathogenesis of coronary artery disease (CAD). MATERIALS AND METHODS: To investigate the relationship between the common single nucleotide polymorphisms (SNPs) 584C/T (rs2000813) and −384A/C (rs3813082) in the LIPG gene and CAD, allele and genotype frequencies of the two SNPs were analysed in 287 Chinese patients with CAD and 367 controls by the high-resolution melting curve (HRM) method. RESULTS: For 584C/T, no significant difference in polymorphic distribution was observed between patients and controls. However, the frequencies of allele C (20.2% vs 15%, p=0.013, OR=1.437, 95% CI 1.078 to 1.915) at −384A/C were significantly increased in patients compared with controls. Haplotype analysis also showed that haplotype CT (12.37% vs 8.72%, p=0.035, OR=1.478, 95% CI 1.034 to 2.112) was significantly higher in patients compared with controls. CONCLUSIONS: These results suggested that the SNP −384A/C in the LIPG gene may be associated with risk for CAD and the LIPG gene may play a role in CAD in the Han Chinese. BMJ Publishing Group 2015-06-29 /pmc/articles/PMC4486941/ /pubmed/26124511 http://dx.doi.org/10.1136/bmjopen-2015-007621 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Genetics and Genomics Xie, Liang Sun, Yan Tong, Yu Liu, Ying Deng, Ying Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people |
title | Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people |
title_full | Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people |
title_fullStr | Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people |
title_full_unstemmed | Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people |
title_short | Association of endothelial lipase gene−384A/C with coronary artery disease in Han Chinese people |
title_sort | association of endothelial lipase gene−384a/c with coronary artery disease in han chinese people |
topic | Genetics and Genomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486941/ https://www.ncbi.nlm.nih.gov/pubmed/26124511 http://dx.doi.org/10.1136/bmjopen-2015-007621 |
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