Understanding Heterogeneity and Permeability of Brain Metastases in Murine Models of HER2-Positive Breast Cancer Through Magnetic Resonance Imaging: Implications for Detection and Therapy

OBJECTIVES: Brain metastases due to breast cancer are increasing, and the prognosis is poor. Lack of effective therapy is attributed to heterogeneity of breast cancers and their resulting metastases, as well as impermeability of the blood–brain barrier (BBB), which hinders delivery of therapeutics t...

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Detalles Bibliográficos
Autores principales: Murrell, Donna H., Hamilton, Amanda M., Mallett, Christiane L., van Gorkum, Robbert, Chambers, Ann F., Foster, Paula J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487267/
https://www.ncbi.nlm.nih.gov/pubmed/26055175
http://dx.doi.org/10.1016/j.tranon.2015.03.009

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