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Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study
BACKGROUND: Cognitive impairment and depression frequently co-occur in late life. There remains a need to better characterize psychosocial risk factors of cognitive decline in older adults with depression. We hypothesized that certain psychosocial factors would be associated with higher risk of cogn...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Canadian Geriatrics Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487735/ https://www.ncbi.nlm.nih.gov/pubmed/26180559 http://dx.doi.org/10.5770/cgj.18.134 |
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author | Rej, Soham Begley, Amy Gildengers, Ariel Dew, Mary Amanda Reynolds, Charles F. Butters, Meryl A. |
author_facet | Rej, Soham Begley, Amy Gildengers, Ariel Dew, Mary Amanda Reynolds, Charles F. Butters, Meryl A. |
author_sort | Rej, Soham |
collection | PubMed |
description | BACKGROUND: Cognitive impairment and depression frequently co-occur in late life. There remains a need to better characterize psychosocial risk factors of cognitive decline in older adults with depression. We hypothesized that certain psychosocial factors would be associated with higher risk of cognitive decline in individuals with late-life depression. METHODS: 130 individuals aged ≥ 65 years who had achieved remission from a major depressive episode were randomized to donepezil or placebo and then closely followed for two years. Using Cox proportional hazard models, we examined the association between baseline median household income, education level, race, marital status, and social support and cognitive decline over the follow-up. RESULTS: Lower interpersonal support (OR = 0.86 [0.74–0.99], p = .04) and lower baseline global neuropsychological score (OR = 0.56 [0.36–0.87], p = .001) predicted shorter time to conversion to MCI or dementia in univariate models. These exposures did not remain significant in multivariate analyses. Neither socioeconomic status nor other psychosocial factors independently predicted cognitive diagnostic conversion (p > .05). CONCLUSIONS: We did not find reliable associations between cognitive outcome and any of the psychosocial factors examined. Future large-scale, epidemiological studies, ideally using well-validated subjective measures, should better characterize psychosocial risk factors for cognitive decline in late-life depression. |
format | Online Article Text |
id | pubmed-4487735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Canadian Geriatrics Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-44877352015-07-15 Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study Rej, Soham Begley, Amy Gildengers, Ariel Dew, Mary Amanda Reynolds, Charles F. Butters, Meryl A. Can Geriatr J Original Research BACKGROUND: Cognitive impairment and depression frequently co-occur in late life. There remains a need to better characterize psychosocial risk factors of cognitive decline in older adults with depression. We hypothesized that certain psychosocial factors would be associated with higher risk of cognitive decline in individuals with late-life depression. METHODS: 130 individuals aged ≥ 65 years who had achieved remission from a major depressive episode were randomized to donepezil or placebo and then closely followed for two years. Using Cox proportional hazard models, we examined the association between baseline median household income, education level, race, marital status, and social support and cognitive decline over the follow-up. RESULTS: Lower interpersonal support (OR = 0.86 [0.74–0.99], p = .04) and lower baseline global neuropsychological score (OR = 0.56 [0.36–0.87], p = .001) predicted shorter time to conversion to MCI or dementia in univariate models. These exposures did not remain significant in multivariate analyses. Neither socioeconomic status nor other psychosocial factors independently predicted cognitive diagnostic conversion (p > .05). CONCLUSIONS: We did not find reliable associations between cognitive outcome and any of the psychosocial factors examined. Future large-scale, epidemiological studies, ideally using well-validated subjective measures, should better characterize psychosocial risk factors for cognitive decline in late-life depression. Canadian Geriatrics Society 2015-06-30 /pmc/articles/PMC4487735/ /pubmed/26180559 http://dx.doi.org/10.5770/cgj.18.134 Text en © 2015 Author(s). Published by the Canadian Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No-Derivative license (http://creativecommons.org/licenses/by-nc-nd/2.5/ca/), which permits unrestricted non-commercial use and distribution, provided the original work is properly cited. |
spellingShingle | Original Research Rej, Soham Begley, Amy Gildengers, Ariel Dew, Mary Amanda Reynolds, Charles F. Butters, Meryl A. Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study |
title | Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study |
title_full | Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study |
title_fullStr | Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study |
title_full_unstemmed | Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study |
title_short | Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study |
title_sort | psychosocial risk factors for cognitive decline in late-life depression: findings from the mtld-iii study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487735/ https://www.ncbi.nlm.nih.gov/pubmed/26180559 http://dx.doi.org/10.5770/cgj.18.134 |
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