Cargando…
Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children
Background. Insulin induced gene 2 (INSIG2) encodes a protein that has a biological effect on regulation of adipocyte metabolism and body weight. This study aimed to investigate the association of INSIG2 gene -102G>A polymorphism with obesity related phenotypes in Chinese children and test gender...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487926/ https://www.ncbi.nlm.nih.gov/pubmed/26161092 http://dx.doi.org/10.1155/2015/872506 |
_version_ | 1782379060851113984 |
---|---|
author | Liu, Fang-Hong Song, Jie-Yun Zhang, Yi-Ning Ma, Jun Wang, Hai-Jun |
author_facet | Liu, Fang-Hong Song, Jie-Yun Zhang, Yi-Ning Ma, Jun Wang, Hai-Jun |
author_sort | Liu, Fang-Hong |
collection | PubMed |
description | Background. Insulin induced gene 2 (INSIG2) encodes a protein that has a biological effect on regulation of adipocyte metabolism and body weight. This study aimed to investigate the association of INSIG2 gene -102G>A polymorphism with obesity related phenotypes in Chinese children and test gender-specific effects. Methods. The 2,030 independent individuals aged from 7 to 18 years, including 705 obese cases and 1,325 nonobese controls, were recruited from local schools. We measured the obesity-related phenotypes and detected the serum lipids. We genotype -102G>A polymorphism by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results. In all individuals, we found that the GG/GA genotype of INSIG2 -102G>A polymorphism was associated with risk of severe obesity (OR = 1.62, 95% CI: 1.11–2.36, and P = 0.012) under the dominant model. The association with severe obesity existed only in boys (OR = 1.91, 95% CI: 1.15–3.17, P = 0.012). The GG/GA genotype of -102G>A polymorphism was also associated with higher waist circumference (β = 2.61 cm, P = 0.031) in boys. No similar association was found in girls. The polymorphism was not associated with other obesity-related phenotypes, neither in all individuals nor in gender-specific population. Conclusions. This study identified a gender-specific effect of INSIG2 -102G>A polymorphism on risk of severe obesity and waist circumference in Chinese boys. |
format | Online Article Text |
id | pubmed-4487926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44879262015-07-09 Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children Liu, Fang-Hong Song, Jie-Yun Zhang, Yi-Ning Ma, Jun Wang, Hai-Jun Int J Endocrinol Research Article Background. Insulin induced gene 2 (INSIG2) encodes a protein that has a biological effect on regulation of adipocyte metabolism and body weight. This study aimed to investigate the association of INSIG2 gene -102G>A polymorphism with obesity related phenotypes in Chinese children and test gender-specific effects. Methods. The 2,030 independent individuals aged from 7 to 18 years, including 705 obese cases and 1,325 nonobese controls, were recruited from local schools. We measured the obesity-related phenotypes and detected the serum lipids. We genotype -102G>A polymorphism by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results. In all individuals, we found that the GG/GA genotype of INSIG2 -102G>A polymorphism was associated with risk of severe obesity (OR = 1.62, 95% CI: 1.11–2.36, and P = 0.012) under the dominant model. The association with severe obesity existed only in boys (OR = 1.91, 95% CI: 1.15–3.17, P = 0.012). The GG/GA genotype of -102G>A polymorphism was also associated with higher waist circumference (β = 2.61 cm, P = 0.031) in boys. No similar association was found in girls. The polymorphism was not associated with other obesity-related phenotypes, neither in all individuals nor in gender-specific population. Conclusions. This study identified a gender-specific effect of INSIG2 -102G>A polymorphism on risk of severe obesity and waist circumference in Chinese boys. Hindawi Publishing Corporation 2015 2015-06-16 /pmc/articles/PMC4487926/ /pubmed/26161092 http://dx.doi.org/10.1155/2015/872506 Text en Copyright © 2015 Fang-Hong Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Fang-Hong Song, Jie-Yun Zhang, Yi-Ning Ma, Jun Wang, Hai-Jun Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children |
title | Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children |
title_full | Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children |
title_fullStr | Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children |
title_full_unstemmed | Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children |
title_short | Gender-Specific Effect of -102G>A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children |
title_sort | gender-specific effect of -102g>a polymorphism in insulin induced gene 2 on obesity in chinese children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487926/ https://www.ncbi.nlm.nih.gov/pubmed/26161092 http://dx.doi.org/10.1155/2015/872506 |
work_keys_str_mv | AT liufanghong genderspecificeffectof102gapolymorphismininsulininducedgene2onobesityinchinesechildren AT songjieyun genderspecificeffectof102gapolymorphismininsulininducedgene2onobesityinchinesechildren AT zhangyining genderspecificeffectof102gapolymorphismininsulininducedgene2onobesityinchinesechildren AT majun genderspecificeffectof102gapolymorphismininsulininducedgene2onobesityinchinesechildren AT wanghaijun genderspecificeffectof102gapolymorphismininsulininducedgene2onobesityinchinesechildren |