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Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters
Brasenia schreberi (蓴菜 chún cài) is an invasive aquatic weed found in the USA, but the plant has economic value in Asia where it is cultivated for food. The young leaves of B. schreberi are coated with gelatinous water-insoluble mucilage. This mucilage is a polysaccharide composed of galactose, mann...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488095/ https://www.ncbi.nlm.nih.gov/pubmed/26151010 http://dx.doi.org/10.1016/j.jtcme.2014.10.003 |
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author | Kim, Hyunsook Wang, Qian Shoemaker, Charles F. Zhong, Fang Bartley, Glenn E. Yokoyama, Wallace H. |
author_facet | Kim, Hyunsook Wang, Qian Shoemaker, Charles F. Zhong, Fang Bartley, Glenn E. Yokoyama, Wallace H. |
author_sort | Kim, Hyunsook |
collection | PubMed |
description | Brasenia schreberi (蓴菜 chún cài) is an invasive aquatic weed found in the USA, but the plant has economic value in Asia where it is cultivated for food. The young leaves of B. schreberi are coated with gelatinous water-insoluble mucilage. This mucilage is a polysaccharide composed of galactose, mannose, fucose, and other monosaccharides. Because some carbohydrate gels are hypocholesterolemic, we evaluated their cholesterol-lowering properties in male hamsters fed hypercholesterolemic diets containing 2% gel coat from B. schreberi (GEL), or 1% cholestyramine (CA), or 5% hydroxypropyl methylcellulose (HPMC), and compared them to 5% microcrystalline cellulose (control) for 3 weeks. We found that very-low-density lipoprotein-, low-density lipoprotein-, and total-cholesterol concentrations in plasma were significantly lowered by GEL, CA, and HPMC compared to control. High-density lipoprotein-cholesterol concentration was lowered by CA and HPMC. Body weights and abdominal adipose tissue weight of GEL and control group animals were greater than those of the CA and HPMC groups. Fecal lipid excretion was greater in the CA and HPMC groups than in the control group. Expression of hepatic CYP51 and CYP7A1 mRNA was upregulated by CA, HPMC, and GEL, indicating increased hepatic cholesterol and bile acid synthesis. Expression of low-density lipoprotein receptor mRNA was upregulated by all treatments. These results suggest that modulation of hepatic expression of cholesterol and bile acid metabolism-regulated genes contributes to the cholesterol-lowering effects of GEL. |
format | Online Article Text |
id | pubmed-4488095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-44880952015-07-06 Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters Kim, Hyunsook Wang, Qian Shoemaker, Charles F. Zhong, Fang Bartley, Glenn E. Yokoyama, Wallace H. J Tradit Complement Med Short Communication Brasenia schreberi (蓴菜 chún cài) is an invasive aquatic weed found in the USA, but the plant has economic value in Asia where it is cultivated for food. The young leaves of B. schreberi are coated with gelatinous water-insoluble mucilage. This mucilage is a polysaccharide composed of galactose, mannose, fucose, and other monosaccharides. Because some carbohydrate gels are hypocholesterolemic, we evaluated their cholesterol-lowering properties in male hamsters fed hypercholesterolemic diets containing 2% gel coat from B. schreberi (GEL), or 1% cholestyramine (CA), or 5% hydroxypropyl methylcellulose (HPMC), and compared them to 5% microcrystalline cellulose (control) for 3 weeks. We found that very-low-density lipoprotein-, low-density lipoprotein-, and total-cholesterol concentrations in plasma were significantly lowered by GEL, CA, and HPMC compared to control. High-density lipoprotein-cholesterol concentration was lowered by CA and HPMC. Body weights and abdominal adipose tissue weight of GEL and control group animals were greater than those of the CA and HPMC groups. Fecal lipid excretion was greater in the CA and HPMC groups than in the control group. Expression of hepatic CYP51 and CYP7A1 mRNA was upregulated by CA, HPMC, and GEL, indicating increased hepatic cholesterol and bile acid synthesis. Expression of low-density lipoprotein receptor mRNA was upregulated by all treatments. These results suggest that modulation of hepatic expression of cholesterol and bile acid metabolism-regulated genes contributes to the cholesterol-lowering effects of GEL. Elsevier 2014-12-16 /pmc/articles/PMC4488095/ /pubmed/26151010 http://dx.doi.org/10.1016/j.jtcme.2014.10.003 Text en http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Short Communication Kim, Hyunsook Wang, Qian Shoemaker, Charles F. Zhong, Fang Bartley, Glenn E. Yokoyama, Wallace H. Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters |
title | Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters |
title_full | Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters |
title_fullStr | Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters |
title_full_unstemmed | Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters |
title_short | Polysaccharide gel coating of the leaves of Brasenia schreberi lowers plasma cholesterol in hamsters |
title_sort | polysaccharide gel coating of the leaves of brasenia schreberi lowers plasma cholesterol in hamsters |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488095/ https://www.ncbi.nlm.nih.gov/pubmed/26151010 http://dx.doi.org/10.1016/j.jtcme.2014.10.003 |
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