Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway

Chronic hyperglycemia increases apoptosis and reduces glucose-stimulated insulin secretion. Although protective agents have been searched extensively, none has been found so far. Here we tested FLZ, a synthetic derivative of squamosamide from a Chinese herb, as a potential candidate for antiglucotox...

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Detalles Bibliográficos
Autores principales: Kong, Xiangchen, Zhang, Longmei, Hua, Xianxin, Ma, Xiaosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488173/
https://www.ncbi.nlm.nih.gov/pubmed/26167511
http://dx.doi.org/10.1155/2015/803986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488173/
https://www.ncbi.nlm.nih.gov/pubmed/26167511
http://dx.doi.org/10.1155/2015/803986

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