Cargando…

Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway

Chronic hyperglycemia increases apoptosis and reduces glucose-stimulated insulin secretion. Although protective agents have been searched extensively, none has been found so far. Here we tested FLZ, a synthetic derivative of squamosamide from a Chinese herb, as a potential candidate for antiglucotox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Xiangchen, Zhang, Longmei, Hua, Xianxin, Ma, Xiaosong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488173/ https://www.ncbi.nlm.nih.gov/pubmed/26167511 http://dx.doi.org/10.1155/2015/803986

Ejemplares similares

Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1
por: Yang, Hanyu, et al.
Publicado: (2021)

Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
por: Zhang, Dan, et al.
Publicado: (2008)

Squamosamide Derivative FLZ Protects Retinal Pigment Epithelium Cells from Oxidative Stress through Activation of Epidermal Growth Factor Receptor (EGFR)-AKT Signaling
por: Cheng, Li-Bo, et al.
Publicado: (2014)

The role of membrane excitability in pancreatic β-cell glucotoxicity
por: Shyr, Zeenat A., et al.
Publicado: (2019)

The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
por: Yoon, Ji Sung, et al.
Publicado: (2016)

Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression
por: Kong, Xiangchen, et al.
Publicado: (2019)

GLP-1 signaling suppresses menin’s transcriptional block by phosphorylation in β cells
por: Xing, Bowen, et al.
Publicado: (2019)

Menin Upregulates FOXO1 Protein Stability by Repressing Skp2-Mediated Degradation in β Cells
por: Jiang, Zongzhe, et al.
Publicado: (2019)

Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction
por: Shu, Tingting, et al.
Publicado: (2019)

FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells
por: Kong, Xiangchen, et al.
Publicado: (2019)

Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?
por: Chae, Heeyoung, et al.
Publicado: (2015)

HM-Chromanone Isolated from Portulaca Oleracea L. Protects INS-1 Pancreatic β Cells against Glucotoxicity-Induced Apoptosis
por: Park, Jae Eun, et al.
Publicado: (2019)

Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells
por: Hwang, In-Hu, et al.
Publicado: (2016)

Genome-wide Identification and Characterization of FCS-Like Zinc Finger (FLZ) Family Genes in Maize (Zea mays) and Functional Analysis of ZmFLZ25 in Plant Abscisic Acid Response
por: Chen, Shunquan, et al.
Publicado: (2021)

Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca(2+) response to glucose
por: Yanagida, Kazuhiro, et al.
Publicado: (2014)

Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson's disease treatment
por: Shang, Junmei, et al.
Publicado: (2021)

The glucotoxicity protecting effect of honokiol in human hepatocytes via directly activating AMPK
por: Liu, Hui, et al.
Publicado: (2022)

Lin28a ameliorates glucotoxicity-induced β-cell dysfunction and apoptosis
por: Hwang, Yeo Jin, et al.
Publicado: (2021)

FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer’s Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation
por: Bao, Xiu-Qi, et al.
Publicado: (2013)

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion
por: Oberhauser, Lucie, et al.
Publicado: (2021)

Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
por: Katz, Liora S., et al.
Publicado: (2022)

Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity
por: Liang, Chen, et al.
Publicado: (2019)

Aloe-Emodin Protects RIN-5F (Pancreatic β-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3
por: Alshatwi, Ali A, et al.
Publicado: (2016)

Quercetin Preserves β-Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation
por: Li, Jian-Mei, et al.
Publicado: (2013)

Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets
por: Costes, Safia, et al.
Publicado: (2009)

Erratum to “Aloe-Emodin Protects RIN-5F (Pancreatic β-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3”
por: Alshatwi, Ali A, et al.
Publicado: (2016)

Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
por: Katz, Liora S., et al.
Publicado: (2022)

Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications
por: Zheng, Hong, et al.
Publicado: (2016)

Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
por: Pignalosa, Francesca Chiara, et al.
Publicado: (2021)

Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity
por: Li, Ning, et al.
Publicado: (2017)

An In Vivo Microdialysis Study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson's Disease Model Rats
por: Hou, Jinfeng, et al.
Publicado: (2014)

MiR-190 ameliorates glucotoxicity-induced dysfunction and apoptosis of pancreatic β-cells by inhibiting NOX2-mediated reactive oxygen species production
por: Lu, Huinan, et al.
Publicado: (2022)

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure
por: Kluth, O., et al.
Publicado: (2010)

Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells
por: Elumalai, Suma, et al.
Publicado: (2016)

CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy
por: Zhao, Chen, et al.
Publicado: (2022)

Glutamate alleviates muscle protein loss by modulating TLR4, NODs, Akt/FOXO and mTOR signaling pathways in LPS-challenged piglets
por: Kang, Ping, et al.
Publicado: (2017)

The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling
por: Liu, Na, et al.
Publicado: (2023)

Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity
por: Wu, Jinzi, et al.
Publicado: (2015)

Which Factor Determines the Duration Required for Relief of Glucotoxicity by the Intensive Insulin Therapy?
por: Yanai, Hidekatsu, et al.
Publicado: (2018)

Genome-wide identification and expression reveal the involvement of the FCS-like zinc finger (FLZ) gene family in Gossypium hirsutum at low temperature
por: Wang, JunDuo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8p2lhvofar45esfh8uecfqnv8a