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Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes

Autoimmunity is associated with defective phagocytic clearance of apoptotic cells. IgM deficient mice exhibit an autoimmune phenotype consistent with a role for circulating IgM antibodies in apoptotic cell clearance. We have extensively characterised IgM binding to non-apoptotic and apoptotic mouse...

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Detalles Bibliográficos
Autores principales:	Hesketh, Emily E., Dransfield, Ian, Kluth, David C., Hughes, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488261/ https://www.ncbi.nlm.nih.gov/pubmed/26121639 http://dx.doi.org/10.1371/journal.pone.0131849

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