Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease

Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inositol kinase Itpkb in mature T lymphocytes results i...

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Detalles Bibliográficos
Autores principales: Miller, Andrew T., Dahlberg, Carol, Sandberg, Mark L., Wen, Ben G., Beisner, Daniel R., Hoerter, John A. H., Parker, Albert, Schmedt, Christian, Stinson, Monique, Avis, Jacqueline, Cienfuegos, Cynthia, McPate, Mark, Tranter, Pamela, Gosling, Martin, Groot-Kormelink, Paul J., Dawson, Janet, Pan, Shifeng, Tian, Shin-Shay, Seidel, H. Martin, Cooke, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488288/
https://www.ncbi.nlm.nih.gov/pubmed/26121493
http://dx.doi.org/10.1371/journal.pone.0131071

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