Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers

Somatic mutations in the nuclear genome are required for tumor formation, but the functional consequences of somatic mitochondrial DNA (mtDNA) mutations are less understood. Here we identify somatic mtDNA mutations across 527 tumors and 14 cancer types, using an approach that takes advantage of evid...

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Detalles Bibliográficos
Autores principales: Stewart, James B., Alaei-Mahabadi, Babak, Sabarinathan, Radhakrishnan, Samuelsson, Tore, Gorodkin, Jan, Gustafsson, Claes M., Larsson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488357/
https://www.ncbi.nlm.nih.gov/pubmed/26125550
http://dx.doi.org/10.1371/journal.pgen.1005333

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