A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers

Infectious prions contain a self-propagating, misfolded conformer of the prion protein termed PrP(Sc). A critical prediction of the protein-only hypothesis is that autocatalytic PrP(Sc) molecules should be infectious. However, some autocatalytic recombinant PrP(Sc) molecules have low or undetectable...

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Detalles Bibliográficos
Autores principales: Noble, Geoffrey P., Wang, Daphne W., Walsh, Daniel J., Barone, Justin R., Miller, Michael B., Nishina, Koren A., Li, Sheng, Supattapone, Surachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488359/
https://www.ncbi.nlm.nih.gov/pubmed/26125623
http://dx.doi.org/10.1371/journal.ppat.1005017

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