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Lymphangiosarcoma with bone formation of the auricle in a dog
A 12-year-old mixed-breed neutered female dog was referred with cutaneous tumors at the left auricle. Histologically, the cutaneous tumor located in the dermis comprised numerous clefts and cavernous channels lined by neoplastic endothelial cells with no erythrocytes. Bone tissue without direct cont...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488415/ https://www.ncbi.nlm.nih.gov/pubmed/25716121 http://dx.doi.org/10.1292/jvms.14-0682 |
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author | MINESHIGE, Takayuki SUGAHARA, Go OHMURO, Tamio KAMIIE, Junichi SHIROTA, Kinji |
author_facet | MINESHIGE, Takayuki SUGAHARA, Go OHMURO, Tamio KAMIIE, Junichi SHIROTA, Kinji |
author_sort | MINESHIGE, Takayuki |
collection | PubMed |
description | A 12-year-old mixed-breed neutered female dog was referred with cutaneous tumors at the left auricle. Histologically, the cutaneous tumor located in the dermis comprised numerous clefts and cavernous channels lined by neoplastic endothelial cells with no erythrocytes. Bone tissue without direct contact with neoplastic cells was seen in the well-developed stromal connective tissue. The neoplastic endothelial cells exhibited mild to moderate atypia. Immunohistochemically, neoplastic cells were positive for vimentin and negative for cytokeratin and factor VIII-related antigen. Basement membrane around the neoplastic lumens was positive for laminin in a linear or granular pattern. Ultrastructural examination revealed discontinuous basement membrane beneath the tumor cells. Histopathological features of this case were consistent with lymphangiosarcoma, and stromal ossification was characteristic. |
format | Online Article Text |
id | pubmed-4488415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44884152015-07-06 Lymphangiosarcoma with bone formation of the auricle in a dog MINESHIGE, Takayuki SUGAHARA, Go OHMURO, Tamio KAMIIE, Junichi SHIROTA, Kinji J Vet Med Sci Pathology A 12-year-old mixed-breed neutered female dog was referred with cutaneous tumors at the left auricle. Histologically, the cutaneous tumor located in the dermis comprised numerous clefts and cavernous channels lined by neoplastic endothelial cells with no erythrocytes. Bone tissue without direct contact with neoplastic cells was seen in the well-developed stromal connective tissue. The neoplastic endothelial cells exhibited mild to moderate atypia. Immunohistochemically, neoplastic cells were positive for vimentin and negative for cytokeratin and factor VIII-related antigen. Basement membrane around the neoplastic lumens was positive for laminin in a linear or granular pattern. Ultrastructural examination revealed discontinuous basement membrane beneath the tumor cells. Histopathological features of this case were consistent with lymphangiosarcoma, and stromal ossification was characteristic. The Japanese Society of Veterinary Science 2015-02-12 2015-06 /pmc/articles/PMC4488415/ /pubmed/25716121 http://dx.doi.org/10.1292/jvms.14-0682 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Pathology MINESHIGE, Takayuki SUGAHARA, Go OHMURO, Tamio KAMIIE, Junichi SHIROTA, Kinji Lymphangiosarcoma with bone formation of the auricle in a dog |
title | Lymphangiosarcoma with bone formation of the auricle in a dog |
title_full | Lymphangiosarcoma with bone formation of the auricle in a dog |
title_fullStr | Lymphangiosarcoma with bone formation of the auricle in a dog |
title_full_unstemmed | Lymphangiosarcoma with bone formation of the auricle in a dog |
title_short | Lymphangiosarcoma with bone formation of the auricle in a dog |
title_sort | lymphangiosarcoma with bone formation of the auricle in a dog |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488415/ https://www.ncbi.nlm.nih.gov/pubmed/25716121 http://dx.doi.org/10.1292/jvms.14-0682 |
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