Evidence for the Use of Multiple Mechanisms by Herpes Simplex Virus-1 R7020 to Inhibit Intimal Hyperplasia

Intimal hyperplasia (IH) is the primary cause of vein bypass graft failure. The smooth muscle cell (SMC) is a key element of IH as it phenotypically switches from a contractile to a synthetic state which can become pathological. R7020, which is an engineered strain of Herpes Simplex Virus-1, inhibit...

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Detalles Bibliográficos
Autores principales: McCormick, Susan, He, Qi, Stern, Jordan, Khodarev, Nikolai, Weichselbaum, Ralph, Skelly, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488439/
https://www.ncbi.nlm.nih.gov/pubmed/26132411
http://dx.doi.org/10.1371/journal.pone.0130264

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