A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats

Activation of hepatic stellate cells (HSCs) is a critical event in process of hepatic fibrogenesis and cirrhosis. Matrine, the active ingredient of Sophora, had been used for clinical treatment of acute/chronic liver disease. However, its potency was low. We prepared a high potency and low toxicity...

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Detalles Bibliográficos
Autores principales: Xu, Yang, Peng, Zhangxiao, Ji, Weidan, Li, Xiang, Lin, Xuejing, Qian, Liqiang, Li, Xiaoya, Chai, Xiaoyun, Wu, Qiuye, Gao, Quangen, Su, Changqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488526/
https://www.ncbi.nlm.nih.gov/pubmed/26167476
http://dx.doi.org/10.1155/2015/203978

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