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Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models
INTRODUCTION: To clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound. METHODS: Normal liver rats were divided into a DKT 90 mg/kg, DKT 270 mg/kg administered group, and control, while cirrhotic liver rats were divided into a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488562/ https://www.ncbi.nlm.nih.gov/pubmed/26155361 http://dx.doi.org/10.1016/j.amsu.2015.05.008 |
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author | Muraoka, Izumi Takatsuki, Mitsuhisa Soyama, Akihiko Yamaguchi, Izumi Tanaka, Shiro Tanaka, Takayuki Kinoshita, Ayaka Hara, Takanobu Kuroki, Tamotsu Eguchi, Susumu |
author_facet | Muraoka, Izumi Takatsuki, Mitsuhisa Soyama, Akihiko Yamaguchi, Izumi Tanaka, Shiro Tanaka, Takayuki Kinoshita, Ayaka Hara, Takanobu Kuroki, Tamotsu Eguchi, Susumu |
author_sort | Muraoka, Izumi |
collection | PubMed |
description | INTRODUCTION: To clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound. METHODS: Normal liver rats were divided into a DKT 90 mg/kg, DKT 270 mg/kg administered group, and control, while cirrhotic liver rats were divided into a DKT-LC 90 mg/kg administered group and Control-LC. The PBF was measured after the administration of either DKT or water for 60 min by laser Doppler flowmetry system. RESULTS: The PBF in the DKT 90 increased approximately 10 min after DKT was administrated, and elevated levels were maintained for approximately 10 min. A comparison of the increase in PBF by the calculating the area under the curve (AUC) revealed that flow was significantly higher in the DKT 90 compared to either the control or the DKT 270 (p < 0.05). The cirrhotic liver group showed stable PBF in both the DKT-LC and Control-LC. The AUC, revealed no significant difference between the DKT-LC and Control-LC. DISCUSSION: DKT induced an increase in PBF in normal livers; however, its effects were insufficient to increase PBF in the cirrhotic livers. No increase in the portal blood flow in the cirrhotic liver rats was probably the result of the cirrhotic liver, which had fibrotic change, and, therefore, may not have had sufficient compliance to accept the increasing blood flow volume from the intestinal tract. CONCLUSION: We suggested DKT has the potential to protect the liver by increasing PBF when the liver has either normal or mild to moderate dysfunction. |
format | Online Article Text |
id | pubmed-4488562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-44885622015-07-07 Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models Muraoka, Izumi Takatsuki, Mitsuhisa Soyama, Akihiko Yamaguchi, Izumi Tanaka, Shiro Tanaka, Takayuki Kinoshita, Ayaka Hara, Takanobu Kuroki, Tamotsu Eguchi, Susumu Ann Med Surg (Lond) Original Research INTRODUCTION: To clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound. METHODS: Normal liver rats were divided into a DKT 90 mg/kg, DKT 270 mg/kg administered group, and control, while cirrhotic liver rats were divided into a DKT-LC 90 mg/kg administered group and Control-LC. The PBF was measured after the administration of either DKT or water for 60 min by laser Doppler flowmetry system. RESULTS: The PBF in the DKT 90 increased approximately 10 min after DKT was administrated, and elevated levels were maintained for approximately 10 min. A comparison of the increase in PBF by the calculating the area under the curve (AUC) revealed that flow was significantly higher in the DKT 90 compared to either the control or the DKT 270 (p < 0.05). The cirrhotic liver group showed stable PBF in both the DKT-LC and Control-LC. The AUC, revealed no significant difference between the DKT-LC and Control-LC. DISCUSSION: DKT induced an increase in PBF in normal livers; however, its effects were insufficient to increase PBF in the cirrhotic livers. No increase in the portal blood flow in the cirrhotic liver rats was probably the result of the cirrhotic liver, which had fibrotic change, and, therefore, may not have had sufficient compliance to accept the increasing blood flow volume from the intestinal tract. CONCLUSION: We suggested DKT has the potential to protect the liver by increasing PBF when the liver has either normal or mild to moderate dysfunction. Elsevier 2015-05-30 /pmc/articles/PMC4488562/ /pubmed/26155361 http://dx.doi.org/10.1016/j.amsu.2015.05.008 Text en © 2015 Published by Elsevier Ltd on behalf of IJS Publishing Group Limited. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Muraoka, Izumi Takatsuki, Mitsuhisa Soyama, Akihiko Yamaguchi, Izumi Tanaka, Shiro Tanaka, Takayuki Kinoshita, Ayaka Hara, Takanobu Kuroki, Tamotsu Eguchi, Susumu Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models |
title | Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models |
title_full | Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models |
title_fullStr | Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models |
title_full_unstemmed | Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models |
title_short | Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models |
title_sort | efficiency of herbal medicine dai-kenchu-to on portal blood flow in rat models |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488562/ https://www.ncbi.nlm.nih.gov/pubmed/26155361 http://dx.doi.org/10.1016/j.amsu.2015.05.008 |
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