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Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy

The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North America and the Amerindians from South America....

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Autores principales: Gnabre, John, Bates, Robert, Huang, Ru Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488564/
https://www.ncbi.nlm.nih.gov/pubmed/26151022
http://dx.doi.org/10.1016/j.jtcme.2014.11.024
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author Gnabre, John
Bates, Robert
Huang, Ru Chih
author_facet Gnabre, John
Bates, Robert
Huang, Ru Chih
author_sort Gnabre, John
collection PubMed
description The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North America and the Amerindians from South America. The plant is rich in simple bisphenyl lignans and tricyclic lignans known as cyclolignans. These compounds are responsible for many of the pharmacological activities of extracts of the plants. Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago. Only recently have further studies revealed other crucial activities of the same plant molecules as powerful agents against human immunodeficiency virus, human papillomavirus, cancer, neurodegenerative diseases, and symptoms of aging. Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription. This review summarizes the recent findings on creosote bush lignans. We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies.
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spelling pubmed-44885642015-07-06 Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy Gnabre, John Bates, Robert Huang, Ru Chih J Tradit Complement Med Review Article The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North America and the Amerindians from South America. The plant is rich in simple bisphenyl lignans and tricyclic lignans known as cyclolignans. These compounds are responsible for many of the pharmacological activities of extracts of the plants. Some of these activities, namely antiherpes, antioxidant, antifungal, and anti-inflammatory, were known a century ago. Only recently have further studies revealed other crucial activities of the same plant molecules as powerful agents against human immunodeficiency virus, human papillomavirus, cancer, neurodegenerative diseases, and symptoms of aging. Molecular mechanisms underlying the antiviral and anticancer activities have been elucidated and involve the inhibition of SP1 dependent gene transcription. This review summarizes the recent findings on creosote bush lignans. We introduce the concept of a cocktail of safe well-characterized natural products from the creosote bush that would represent a bridge between oriental herbal medicines and Western drug-based therapies. Elsevier 2015-03-12 /pmc/articles/PMC4488564/ /pubmed/26151022 http://dx.doi.org/10.1016/j.jtcme.2014.11.024 Text en Copyright © 2015, Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Gnabre, John
Bates, Robert
Huang, Ru Chih
Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
title Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
title_full Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
title_fullStr Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
title_full_unstemmed Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
title_short Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy
title_sort creosote bush lignans for human disease treatment and prevention: perspectives on combination therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488564/
https://www.ncbi.nlm.nih.gov/pubmed/26151022
http://dx.doi.org/10.1016/j.jtcme.2014.11.024
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