Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus

The type 2 diabetes mellitus (T2DM) is one of the most serious diseases that threaten public health. Modified gastric bypass surgery has been applied to the treatment of T2DM patients in the 1990s, but the therapeutic mechanism to this function is still unclear. The aim of this study was to further...

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Autores principales: Xiong, Shao-Wei, Cao, Jing, Liu, Xian-Ming, Deng, Xing-Ming, Liu, Zeng, Zhang, Fang-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488585/
https://www.ncbi.nlm.nih.gov/pubmed/26167177
http://dx.doi.org/10.1155/2015/625196
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author Xiong, Shao-Wei
Cao, Jing
Liu, Xian-Ming
Deng, Xing-Ming
Liu, Zeng
Zhang, Fang-Ting
author_facet Xiong, Shao-Wei
Cao, Jing
Liu, Xian-Ming
Deng, Xing-Ming
Liu, Zeng
Zhang, Fang-Ting
author_sort Xiong, Shao-Wei
collection PubMed
description The type 2 diabetes mellitus (T2DM) is one of the most serious diseases that threaten public health. Modified gastric bypass surgery has been applied to the treatment of T2DM patients in the 1990s, but the therapeutic mechanism to this function is still unclear. The aim of this study was to further clarify the effect and the mechanism of modified gastric bypass surgery on glucose metabolism in patients with T2DM. In the study, the incretin indexes and blood glucose indexes were analyzed before surgery and 1 week and 1, 3, and 6 months after surgery. The results suggested that modified Roux-en-Y gastric bypass can promote GLP-1 secretion in patients with T2DM, while reducing the secretion of GIP. Thus it could effectively control blood glucose of patients with T2DM.
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spelling pubmed-44885852015-07-12 Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus Xiong, Shao-Wei Cao, Jing Liu, Xian-Ming Deng, Xing-Ming Liu, Zeng Zhang, Fang-Ting Gastroenterol Res Pract Research Article The type 2 diabetes mellitus (T2DM) is one of the most serious diseases that threaten public health. Modified gastric bypass surgery has been applied to the treatment of T2DM patients in the 1990s, but the therapeutic mechanism to this function is still unclear. The aim of this study was to further clarify the effect and the mechanism of modified gastric bypass surgery on glucose metabolism in patients with T2DM. In the study, the incretin indexes and blood glucose indexes were analyzed before surgery and 1 week and 1, 3, and 6 months after surgery. The results suggested that modified Roux-en-Y gastric bypass can promote GLP-1 secretion in patients with T2DM, while reducing the secretion of GIP. Thus it could effectively control blood glucose of patients with T2DM. Hindawi Publishing Corporation 2015 2015-06-18 /pmc/articles/PMC4488585/ /pubmed/26167177 http://dx.doi.org/10.1155/2015/625196 Text en Copyright © 2015 Shao-Wei Xiong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiong, Shao-Wei
Cao, Jing
Liu, Xian-Ming
Deng, Xing-Ming
Liu, Zeng
Zhang, Fang-Ting
Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
title Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
title_full Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
title_fullStr Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
title_short Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
title_sort effect of modified roux-en-y gastric bypass surgery on glp-1, gip in patients with type 2 diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488585/
https://www.ncbi.nlm.nih.gov/pubmed/26167177
http://dx.doi.org/10.1155/2015/625196
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