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Development of myenteric plexus in human foetuses: a quantitative study

Maturation of neurons of the myenteric plexus (MP) of human fetal sigmoid colon was studied at various weeks of gestation (WG). There is abundant literature on the development of MP in various segments of the gut but there are fewer reports on the development of MP in human sigmoid colon which is a...

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Autores principales: Singh, Seema, Shariff, Ahmadulla, Roy, Tarasankar, Das, Taposh, Rani, Neerja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Anatomists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488640/
https://www.ncbi.nlm.nih.gov/pubmed/26140223
http://dx.doi.org/10.5115/acb.2015.48.2.124
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author Singh, Seema
Shariff, Ahmadulla
Roy, Tarasankar
Das, Taposh
Rani, Neerja
author_facet Singh, Seema
Shariff, Ahmadulla
Roy, Tarasankar
Das, Taposh
Rani, Neerja
author_sort Singh, Seema
collection PubMed
description Maturation of neurons of the myenteric plexus (MP) of human fetal sigmoid colon was studied at various weeks of gestation (WG). There is abundant literature on the development of MP in various segments of the gut but there are fewer reports on the development of MP in human sigmoid colon which is a site of various disorders. Sigmoid colonic segments from 12 aborted foetuses aged 14-23WG were processed for NADPH histochemistry. Stereologic evaluation of the neuronal cell profiles, numerical density, number of neurons per ganglion and myenteric fraction was conducted using using imageJ software. According to gestational age, foetuses were assigned into two groups (group 1 [n=7], less than <17WG and group 2 [n=5], more than >17WG). The overall size of neuronal cell profiles in the MP was significantly increased (P<0.05). The numerical density of neurons decreased in group 2 in comparison to group 1, the number of neurons per ganglion and myenteric fraction were increased in group 2 but all these were not statistically significant. This study revealed that the maturational event increases after 17WG and extensive innervations is established at 23WG. During prenatal life there is an increase in the neuronal cell size from 14-23WG signifying maturational process. Such studies are essential for clinicians and surgeons to correlate the normal and pathologic development of the enteric nervous system.
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spelling pubmed-44886402015-07-02 Development of myenteric plexus in human foetuses: a quantitative study Singh, Seema Shariff, Ahmadulla Roy, Tarasankar Das, Taposh Rani, Neerja Anat Cell Biol Original Article Maturation of neurons of the myenteric plexus (MP) of human fetal sigmoid colon was studied at various weeks of gestation (WG). There is abundant literature on the development of MP in various segments of the gut but there are fewer reports on the development of MP in human sigmoid colon which is a site of various disorders. Sigmoid colonic segments from 12 aborted foetuses aged 14-23WG were processed for NADPH histochemistry. Stereologic evaluation of the neuronal cell profiles, numerical density, number of neurons per ganglion and myenteric fraction was conducted using using imageJ software. According to gestational age, foetuses were assigned into two groups (group 1 [n=7], less than <17WG and group 2 [n=5], more than >17WG). The overall size of neuronal cell profiles in the MP was significantly increased (P<0.05). The numerical density of neurons decreased in group 2 in comparison to group 1, the number of neurons per ganglion and myenteric fraction were increased in group 2 but all these were not statistically significant. This study revealed that the maturational event increases after 17WG and extensive innervations is established at 23WG. During prenatal life there is an increase in the neuronal cell size from 14-23WG signifying maturational process. Such studies are essential for clinicians and surgeons to correlate the normal and pathologic development of the enteric nervous system. Korean Association of Anatomists 2015-06 2015-06-26 /pmc/articles/PMC4488640/ /pubmed/26140223 http://dx.doi.org/10.5115/acb.2015.48.2.124 Text en Copyright © 2015. Anatomy & Cell Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Singh, Seema
Shariff, Ahmadulla
Roy, Tarasankar
Das, Taposh
Rani, Neerja
Development of myenteric plexus in human foetuses: a quantitative study
title Development of myenteric plexus in human foetuses: a quantitative study
title_full Development of myenteric plexus in human foetuses: a quantitative study
title_fullStr Development of myenteric plexus in human foetuses: a quantitative study
title_full_unstemmed Development of myenteric plexus in human foetuses: a quantitative study
title_short Development of myenteric plexus in human foetuses: a quantitative study
title_sort development of myenteric plexus in human foetuses: a quantitative study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488640/
https://www.ncbi.nlm.nih.gov/pubmed/26140223
http://dx.doi.org/10.5115/acb.2015.48.2.124
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