Microsatellite Instability Use in Mismatch Repair Gene Sequence Variant Classification

Inherited mutations in the DNA mismatch repair genes (MMR) can cause MMR deficiency and increased susceptibility to colorectal and endometrial cancer. Microsatellite instability (MSI) is the defining molecular signature of MMR deficiency. The clinical classification of identified MMR gene sequence v...

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Detalles Bibliográficos
Autores principales: Thompson, Bryony A., Spurdle, Amanda B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Discussion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488658/
https://www.ncbi.nlm.nih.gov/pubmed/25831438
http://dx.doi.org/10.3390/genes6020150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488658/
https://www.ncbi.nlm.nih.gov/pubmed/25831438
http://dx.doi.org/10.3390/genes6020150

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