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APOBEC3 Interference during Replication of Viral Genomes

Co-evolution of viruses and their hosts has reached a fragile and dynamic equilibrium that allows viral persistence, replication and transmission. In response, infected hosts have developed strategies of defense that counteract the deleterious effects of viral infections. In particular, single-stran...

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Detalles Bibliográficos
Autores principales: Willems, Luc, Gillet, Nicolas Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488724/
https://www.ncbi.nlm.nih.gov/pubmed/26110583
http://dx.doi.org/10.3390/v7062757
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author Willems, Luc
Gillet, Nicolas Albert
author_facet Willems, Luc
Gillet, Nicolas Albert
author_sort Willems, Luc
collection PubMed
description Co-evolution of viruses and their hosts has reached a fragile and dynamic equilibrium that allows viral persistence, replication and transmission. In response, infected hosts have developed strategies of defense that counteract the deleterious effects of viral infections. In particular, single-strand DNA editing by Apolipoprotein B Editing Catalytic subunits proteins 3 (APOBEC3s) is a well-conserved mechanism of mammalian innate immunity that mutates and inactivates viral genomes. In this review, we describe the mechanisms of APOBEC3 editing during viral replication, the viral strategies that prevent APOBEC3 activity and the consequences of APOBEC3 modulation on viral fitness and host genome integrity. Understanding the mechanisms involved reveals new prospects for therapeutic intervention.
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spelling pubmed-44887242015-07-02 APOBEC3 Interference during Replication of Viral Genomes Willems, Luc Gillet, Nicolas Albert Viruses Review Co-evolution of viruses and their hosts has reached a fragile and dynamic equilibrium that allows viral persistence, replication and transmission. In response, infected hosts have developed strategies of defense that counteract the deleterious effects of viral infections. In particular, single-strand DNA editing by Apolipoprotein B Editing Catalytic subunits proteins 3 (APOBEC3s) is a well-conserved mechanism of mammalian innate immunity that mutates and inactivates viral genomes. In this review, we describe the mechanisms of APOBEC3 editing during viral replication, the viral strategies that prevent APOBEC3 activity and the consequences of APOBEC3 modulation on viral fitness and host genome integrity. Understanding the mechanisms involved reveals new prospects for therapeutic intervention. MDPI 2015-06-11 /pmc/articles/PMC4488724/ /pubmed/26110583 http://dx.doi.org/10.3390/v7062757 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Willems, Luc
Gillet, Nicolas Albert
APOBEC3 Interference during Replication of Viral Genomes
title APOBEC3 Interference during Replication of Viral Genomes
title_full APOBEC3 Interference during Replication of Viral Genomes
title_fullStr APOBEC3 Interference during Replication of Viral Genomes
title_full_unstemmed APOBEC3 Interference during Replication of Viral Genomes
title_short APOBEC3 Interference during Replication of Viral Genomes
title_sort apobec3 interference during replication of viral genomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488724/
https://www.ncbi.nlm.nih.gov/pubmed/26110583
http://dx.doi.org/10.3390/v7062757
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