Antiviral Potential of a Novel Compound CW-33 against Enterovirus A71 via Inhibition of Viral 2A Protease

Enterovirus A71 (EV-A71) in the Picornaviridae family causes hand-foot-and-mouth disease, aseptic meningitis, severe central nervous system disease, even death. EV-A71 2A protease cleaves Type I interferon (IFN)-α/β receptor 1 (IFNAR1) to block IFN-induced Jak/STAT signaling. This study investigated...

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Detalles Bibliográficos
Autores principales: Wang, Ching-Ying, Huang, An-Cheng, Hour, Mann-Jen, Huang, Su-Hua, Kung, Szu-Hao, Chen, Chao-Hsien, Chen, I-Chieh, Chang, Yuan-Shiun, Lien, Jin-Cherng, Lin, Cheng-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488731/
https://www.ncbi.nlm.nih.gov/pubmed/26090728
http://dx.doi.org/10.3390/v7062764

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