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The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece?

In the last decade, vitamin D was in the spotlight in many fields of research. Despite numerous publications, its influence on reproductive health remains ambiguous. This paper presents an up-to-date review of current knowledge concerning the role of cholecalciferol in human reproduction. It covers...

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Autores principales: Dabrowski, Filip A., Grzechocinska, Barbara, Wielgos, Miroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488777/
https://www.ncbi.nlm.nih.gov/pubmed/26035242
http://dx.doi.org/10.3390/nu7064139
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author Dabrowski, Filip A.
Grzechocinska, Barbara
Wielgos, Miroslaw
author_facet Dabrowski, Filip A.
Grzechocinska, Barbara
Wielgos, Miroslaw
author_sort Dabrowski, Filip A.
collection PubMed
description In the last decade, vitamin D was in the spotlight in many fields of research. Despite numerous publications, its influence on reproductive health remains ambiguous. This paper presents an up-to-date review of current knowledge concerning the role of cholecalciferol in human reproduction. It covers various infertility issues, such as polycystic ovary syndrome, endometriosis, myoma-induced infertility, male infertility, premature ovary failure and in vitro fertilization techniques. Vitamin D deficiency, defined as serum concentration of 25-hydroxycalciferol of less than 50 nmol/L, is commonly noted more frequently than only in fertility clinic patients. It is a global trend that is observed in all age groups. The results of original publications dated up to 2015 have been summarized and discussed in a critical manner. Most experts agree that vitamin D supplementation is a necessity, particularly in women suffering from obesity, insulin resistance or small ovarian reserve, as well as in men with oligo- and asthenozoospermia if serum concentration should fall below 50 nmol/L (normal range up to 125 nmol/L). High concentration of vitamin D and its metabolites in decidua during the 1st trimester suggests its important role in the implantation process and a local immunological embryo-protection. On the other hand, evidence-based research did not prove a significant difference so far in ovulation stimulation or embryo development depending on vitamin D level. In one of the publications, it was also found that vitamin D binding protein (VDBP) has a molecular similarity to anti-sperm antibodies, and another one concluded that both low (<50 nmol/L) and high (>125 nmol/L) concentration of vitamin D are associated with decreased number and quality of spermatozoa in semen. Vitamin D is definitely not a Trojan Horse in reproductive health, since there were no adverse effects reported for vitamin D intake of up to 10,000 IU/day, but to proclaim it the Golden Fleece, more evidence is needed.
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spelling pubmed-44887772015-07-02 The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece? Dabrowski, Filip A. Grzechocinska, Barbara Wielgos, Miroslaw Nutrients Review In the last decade, vitamin D was in the spotlight in many fields of research. Despite numerous publications, its influence on reproductive health remains ambiguous. This paper presents an up-to-date review of current knowledge concerning the role of cholecalciferol in human reproduction. It covers various infertility issues, such as polycystic ovary syndrome, endometriosis, myoma-induced infertility, male infertility, premature ovary failure and in vitro fertilization techniques. Vitamin D deficiency, defined as serum concentration of 25-hydroxycalciferol of less than 50 nmol/L, is commonly noted more frequently than only in fertility clinic patients. It is a global trend that is observed in all age groups. The results of original publications dated up to 2015 have been summarized and discussed in a critical manner. Most experts agree that vitamin D supplementation is a necessity, particularly in women suffering from obesity, insulin resistance or small ovarian reserve, as well as in men with oligo- and asthenozoospermia if serum concentration should fall below 50 nmol/L (normal range up to 125 nmol/L). High concentration of vitamin D and its metabolites in decidua during the 1st trimester suggests its important role in the implantation process and a local immunological embryo-protection. On the other hand, evidence-based research did not prove a significant difference so far in ovulation stimulation or embryo development depending on vitamin D level. In one of the publications, it was also found that vitamin D binding protein (VDBP) has a molecular similarity to anti-sperm antibodies, and another one concluded that both low (<50 nmol/L) and high (>125 nmol/L) concentration of vitamin D are associated with decreased number and quality of spermatozoa in semen. Vitamin D is definitely not a Trojan Horse in reproductive health, since there were no adverse effects reported for vitamin D intake of up to 10,000 IU/day, but to proclaim it the Golden Fleece, more evidence is needed. MDPI 2015-05-29 /pmc/articles/PMC4488777/ /pubmed/26035242 http://dx.doi.org/10.3390/nu7064139 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dabrowski, Filip A.
Grzechocinska, Barbara
Wielgos, Miroslaw
The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece?
title The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece?
title_full The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece?
title_fullStr The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece?
title_full_unstemmed The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece?
title_short The Role of Vitamin D in Reproductive Health—A Trojan Horse or the Golden Fleece?
title_sort role of vitamin d in reproductive health—a trojan horse or the golden fleece?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488777/
https://www.ncbi.nlm.nih.gov/pubmed/26035242
http://dx.doi.org/10.3390/nu7064139
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