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Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia

Up to 20% of adult patients with Thalassemia major (Thal) live with diabetes, while 30% may be zinc deficient. The objective of this study was to explore the relationship between zinc status, impaired glucose tolerance and insulin sensitivity in Thal patients. Charts from thirty subjects (16 male, 2...

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Autores principales: Fung, Ellen B., Gildengorin, Ginny, Talwar, Siddhant, Hagar, Leah, Lal, Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488784/
https://www.ncbi.nlm.nih.gov/pubmed/26043030
http://dx.doi.org/10.3390/nu7064296
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author Fung, Ellen B.
Gildengorin, Ginny
Talwar, Siddhant
Hagar, Leah
Lal, Ashutosh
author_facet Fung, Ellen B.
Gildengorin, Ginny
Talwar, Siddhant
Hagar, Leah
Lal, Ashutosh
author_sort Fung, Ellen B.
collection PubMed
description Up to 20% of adult patients with Thalassemia major (Thal) live with diabetes, while 30% may be zinc deficient. The objective of this study was to explore the relationship between zinc status, impaired glucose tolerance and insulin sensitivity in Thal patients. Charts from thirty subjects (16 male, 27.8 ± 9.1 years) with Thal were reviewed. Patients with low serum zinc had significantly lower fasting insulin, insulinogenic and oral disposition indexes (all p < 0.05) and elevated glucose response curve, following a standard 75 g oral load of glucose compared to those with normal serum zinc after controlling for baseline (group × time interaction p = 0.048). Longitudinal data in five patients with a decline in serum zinc over a two year follow up period (−19.0 ± 9.6 μg/dL), showed consistent increases in fasting glucose (3.6 ± 3.2 mg/dL) and insulin to glucose ratios at 120 min post glucose dose (p = 0.05). Taken together, these data suggest that the frequently present zinc deficiency in Thal patients is associated with decreased insulin secretion and reduced glucose disposal. Future zinc trials will require modeling of oral glucose tolerance test data and not simply measurement of static indices in order to understand the complexities of pancreatic function in the Thal patient.
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spelling pubmed-44887842015-07-02 Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia Fung, Ellen B. Gildengorin, Ginny Talwar, Siddhant Hagar, Leah Lal, Ashutosh Nutrients Article Up to 20% of adult patients with Thalassemia major (Thal) live with diabetes, while 30% may be zinc deficient. The objective of this study was to explore the relationship between zinc status, impaired glucose tolerance and insulin sensitivity in Thal patients. Charts from thirty subjects (16 male, 27.8 ± 9.1 years) with Thal were reviewed. Patients with low serum zinc had significantly lower fasting insulin, insulinogenic and oral disposition indexes (all p < 0.05) and elevated glucose response curve, following a standard 75 g oral load of glucose compared to those with normal serum zinc after controlling for baseline (group × time interaction p = 0.048). Longitudinal data in five patients with a decline in serum zinc over a two year follow up period (−19.0 ± 9.6 μg/dL), showed consistent increases in fasting glucose (3.6 ± 3.2 mg/dL) and insulin to glucose ratios at 120 min post glucose dose (p = 0.05). Taken together, these data suggest that the frequently present zinc deficiency in Thal patients is associated with decreased insulin secretion and reduced glucose disposal. Future zinc trials will require modeling of oral glucose tolerance test data and not simply measurement of static indices in order to understand the complexities of pancreatic function in the Thal patient. MDPI 2015-06-02 /pmc/articles/PMC4488784/ /pubmed/26043030 http://dx.doi.org/10.3390/nu7064296 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fung, Ellen B.
Gildengorin, Ginny
Talwar, Siddhant
Hagar, Leah
Lal, Ashutosh
Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia
title Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia
title_full Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia
title_fullStr Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia
title_full_unstemmed Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia
title_short Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia
title_sort zinc status affects glucose homeostasis and insulin secretion in patients with thalassemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488784/
https://www.ncbi.nlm.nih.gov/pubmed/26043030
http://dx.doi.org/10.3390/nu7064296
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