Mechanistic Effects of Calcitriol in Cancer Biology

Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol re...

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Detalles Bibliográficos
Autores principales: Díaz, Lorenza, Díaz-Muñoz, Mauricio, García-Gaytán, Ana Cristina, Méndez, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488829/
https://www.ncbi.nlm.nih.gov/pubmed/26102214
http://dx.doi.org/10.3390/nu7065020
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author Díaz, Lorenza
Díaz-Muñoz, Mauricio
García-Gaytán, Ana Cristina
Méndez, Isabel
author_facet Díaz, Lorenza
Díaz-Muñoz, Mauricio
García-Gaytán, Ana Cristina
Méndez, Isabel
author_sort Díaz, Lorenza
collection PubMed
description Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol.
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spelling pubmed-44888292015-07-02 Mechanistic Effects of Calcitriol in Cancer Biology Díaz, Lorenza Díaz-Muñoz, Mauricio García-Gaytán, Ana Cristina Méndez, Isabel Nutrients Review Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol. MDPI 2015-06-19 /pmc/articles/PMC4488829/ /pubmed/26102214 http://dx.doi.org/10.3390/nu7065020 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Díaz, Lorenza
Díaz-Muñoz, Mauricio
García-Gaytán, Ana Cristina
Méndez, Isabel
Mechanistic Effects of Calcitriol in Cancer Biology
title Mechanistic Effects of Calcitriol in Cancer Biology
title_full Mechanistic Effects of Calcitriol in Cancer Biology
title_fullStr Mechanistic Effects of Calcitriol in Cancer Biology
title_full_unstemmed Mechanistic Effects of Calcitriol in Cancer Biology
title_short Mechanistic Effects of Calcitriol in Cancer Biology
title_sort mechanistic effects of calcitriol in cancer biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488829/
https://www.ncbi.nlm.nih.gov/pubmed/26102214
http://dx.doi.org/10.3390/nu7065020
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