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Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis
Integrating carbon (C), nitrogen (N), and sulfur (S) metabolism is essential for the growth and development of living organisms. MicroRNAs (miRNAs) play key roles in regulating nutrient metabolism in plants. However, how plant miRNAs mediate crosstalk between different nutrient metabolic pathways is...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488870/ https://www.ncbi.nlm.nih.gov/pubmed/26134148 http://dx.doi.org/10.1038/srep11813 |
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author | Liang, Gang Ai, Qin Yu, Diqiu |
author_facet | Liang, Gang Ai, Qin Yu, Diqiu |
author_sort | Liang, Gang |
collection | PubMed |
description | Integrating carbon (C), nitrogen (N), and sulfur (S) metabolism is essential for the growth and development of living organisms. MicroRNAs (miRNAs) play key roles in regulating nutrient metabolism in plants. However, how plant miRNAs mediate crosstalk between different nutrient metabolic pathways is unclear. In this study, deep sequencing of Arabidopsis thaliana small RNAs was used to reveal miRNAs that were differentially expressed in response to C, N, or S deficiency. Comparative analysis revealed that the targets of the differentially expressed miRNAs are involved in different cellular responses and metabolic processes, including transcriptional regulation, auxin signal transduction, nutrient homeostasis, and regulation of development. C, N, and S deficiency specifically induced miR169b/c, miR826 and miR395, respectively. In contrast, miR167, miR172, miR397, miR398, miR399, miR408, miR775, miR827, miR841, miR857, and miR2111 are commonly suppressed by C, N, and S deficiency. In particular, the miRNAs that are induced specifically by a certain nutrient deficiency are often suppressed by other nutrient deficiencies. Further investigation indicated that the modulation of nutrient-responsive miRNA abundance affects the adaptation of plants to nutrient starvation conditions. This study revealed that miRNAs function as important regulatory nodes of different nutrient metabolic pathways. |
format | Online Article Text |
id | pubmed-4488870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44888702015-07-08 Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis Liang, Gang Ai, Qin Yu, Diqiu Sci Rep Article Integrating carbon (C), nitrogen (N), and sulfur (S) metabolism is essential for the growth and development of living organisms. MicroRNAs (miRNAs) play key roles in regulating nutrient metabolism in plants. However, how plant miRNAs mediate crosstalk between different nutrient metabolic pathways is unclear. In this study, deep sequencing of Arabidopsis thaliana small RNAs was used to reveal miRNAs that were differentially expressed in response to C, N, or S deficiency. Comparative analysis revealed that the targets of the differentially expressed miRNAs are involved in different cellular responses and metabolic processes, including transcriptional regulation, auxin signal transduction, nutrient homeostasis, and regulation of development. C, N, and S deficiency specifically induced miR169b/c, miR826 and miR395, respectively. In contrast, miR167, miR172, miR397, miR398, miR399, miR408, miR775, miR827, miR841, miR857, and miR2111 are commonly suppressed by C, N, and S deficiency. In particular, the miRNAs that are induced specifically by a certain nutrient deficiency are often suppressed by other nutrient deficiencies. Further investigation indicated that the modulation of nutrient-responsive miRNA abundance affects the adaptation of plants to nutrient starvation conditions. This study revealed that miRNAs function as important regulatory nodes of different nutrient metabolic pathways. Nature Publishing Group 2015-07-02 /pmc/articles/PMC4488870/ /pubmed/26134148 http://dx.doi.org/10.1038/srep11813 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liang, Gang Ai, Qin Yu, Diqiu Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis |
title | Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis |
title_full | Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis |
title_fullStr | Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis |
title_full_unstemmed | Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis |
title_short | Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis |
title_sort | uncovering mirnas involved in crosstalk between nutrient deficiencies in arabidopsis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488870/ https://www.ncbi.nlm.nih.gov/pubmed/26134148 http://dx.doi.org/10.1038/srep11813 |
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