Cargando…

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

Induction of membrane rearrangements in the cytoplasm of infected cells is a hallmark of positive-strand RNA viruses. These altered membranes serve as scaffolds for the assembly of viral replication factories (RFs). We have recently shown that hepatitis C virus (HCV) infection induces endoplasmic re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Romero-Brey, Inés, Berger, Carola, Kallis, Stephanie, Kolovou, Androniki, Paul, David, Lohmann, Volker, Bartenschlager, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488949/ https://www.ncbi.nlm.nih.gov/pubmed/26152585 http://dx.doi.org/10.1128/mBio.00759-15

Ejemplares similares

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics
por: Kaul, Artur, et al.
Publicado: (2009)

Correction: Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics
por: Kaul, Artur, et al.
Publicado: (2009)

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication
por: Kouretova, Jenny, et al.
Publicado: (2017)

Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus
por: Wahaab, Abdul, et al.
Publicado: (2021)

Membranous Replication Factories Induced by Plus-Strand RNA Viruses
por: Romero-Brey, Inés, et al.
Publicado: (2014)

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly
por: Romero-Brey, Inés, et al.
Publicado: (2016)

The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A
por: Reiss, Simon, et al.
Publicado: (2013)

Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication
por: Pierce, Danielle M., et al.
Publicado: (2023)

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations
por: Pietschmann, Thomas, et al.
Publicado: (2009)

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
por: Li, Anzhong, et al.
Publicado: (2018)

Caveolin-1 in Lipid Rafts Interacts with Dengue Virus NS3 during Polyprotein Processing and Replication in HMEC-1 Cells
por: García Cordero, Julio, et al.
Publicado: (2014)

Determinants of duck Tembusu virus NS2A/2B polyprotein procession attenuated viral replication and proliferation in vitro
por: Jiang, Bowen, et al.
Publicado: (2020)

A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication
por: Isken, Olaf, et al.
Publicado: (2015)

Correction: A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication
por: Isken, Olaf, et al.
Publicado: (2016)

Polyproteins in structural biology
por: Crépin, Thibaut, et al.
Publicado: (2015)

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication
por: Oudshoorn, Diede, et al.
Publicado: (2017)

Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle
por: Binder, Marco, et al.
Publicado: (2013)

Viral Infection at High Magnification: 3D Electron Microscopy Methods to Analyze the Architecture of Infected Cells
por: Romero-Brey, Inés, et al.
Publicado: (2015)

Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication
por: Romero-Brey, Inés, et al.
Publicado: (2012)

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
por: Rausalu, Kai, et al.
Publicado: (2016)

Author Correction: Determinants of duck Tembusu virus NS2A/2B polyprotein procession attenuated viral replication and proliferation in vitro
por: Jiang, Bowen, et al.
Publicado: (2021)

Viral precursor polyproteins: keys of regulation from replication to maturation
por: Yost, Samantha A, et al.
Publicado: (2013)

Polyprotein cleavage mechanism of SARS CoV M(pro) and chemical modification of the octapeptide
por: Du, Qi-Shi, et al.
Publicado: (2004)

Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis
por: Pène, Véronique, et al.
Publicado: (2017)

SARS-CoV-2 polyprotein substrate regulates the stepwise M(pro) cleavage reaction
por: Narwal, Manju, et al.
Publicado: (2023)

Nonexponential kinetics captured in sequential unfolding of polyproteins over a range of loads
por: Chetrit, Einat, et al.
Publicado: (2022)

Identification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element
por: George, Maja, et al.
Publicado: (2011)

Inhibition of 2A-mediated ‘cleavage’ of certain artificial polyproteins bearing N-terminal signal sequences
por: de Felipe, Pablo, et al.
Publicado: (2010)

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A
por: Coelmont, Lotte, et al.
Publicado: (2010)

Hepatitis E virus RNA replication polyprotein: taking structural biology seriously
por: Fieulaine, Sonia, et al.
Publicado: (2023)

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2
por: Zhao, Yao, et al.
Publicado: (2022)

Multiprotein Complex Production in Insect Cells by Using Polyproteins
por: Nie, Yan, et al.
Publicado: (2013)

Differential role of N-Terminal Polyprotein Processing in Coronavirus Genome Replication and Minigenome Amplification
por: Galán, Carmen, et al.
Publicado: (2006)

The HCV Replicase Complex and Viral RNA Synthesis
por: Romero-Brey, Inés, et al.
Publicado: (2016)

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites
por: Welsch, Sonja, et al.
Publicado: (2009)

Identification of Cleavage Sites Recognized by the 3C-Like Cysteine Protease within the Two Polyproteins of Strawberry Mottle Virus
por: Mann, Krin S., et al.
Publicado: (2017)

CRISPR-Cas13a Cleavage of Dengue Virus NS3 Gene Efficiently Inhibits Viral Replication
por: Li, Hao, et al.
Publicado: (2020)

Insights into Polyprotein Processing and RNA-Protein Interactions in Foot-and-Mouth Disease Virus Genome Replication
por: Pierce, Danielle M., et al.
Publicado: (2023)

NS2B/3 proteolysis at the C-prM junction of the tick-borne encephalitis virus polyprotein is highly membrane dependent
por: Kurz, Martina, et al.
Publicado: (2012)

The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication
por: de Chassey, Benoît, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0ddsltgi7kp923cbn0h1qv9hsr