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Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report
CONTEXT: A rare case of adult hairy cell leukemia (HCL) with duodenal involvement is presented. CASE REPORT: The patient was a 48-year-old man, who had a history of hairy cell leukemia. Three days after completion of 2-chlorodeoxyadenosine (CDA) chemotherapy, the patient started experiencing abdomin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488997/ https://www.ncbi.nlm.nih.gov/pubmed/26199927 http://dx.doi.org/10.4103/1947-2714.157489 |
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author | Sen, Parijat Shaaban, Hamid Modi, Tejas Kumar, Abhishek Guron, Gunwant |
author_facet | Sen, Parijat Shaaban, Hamid Modi, Tejas Kumar, Abhishek Guron, Gunwant |
author_sort | Sen, Parijat |
collection | PubMed |
description | CONTEXT: A rare case of adult hairy cell leukemia (HCL) with duodenal involvement is presented. CASE REPORT: The patient was a 48-year-old man, who had a history of hairy cell leukemia. Three days after completion of 2-chlorodeoxyadenosine (CDA) chemotherapy, the patient started experiencing abdominal pain. An extensive gastroenterological workup culminated in the patient getting an esophagogastroduodenoscopy (EGD) that revealed duodenal inflammation and biopsies were taken. The duodenal biopsy was positive for chronic inflammatory infiltrate, primarily consisting of atypical lymphocytes and plasma cells with tartrate-resistant acid phosphatase (TRAP) positivity, and hence a diagnosis of duodenal involvement with HCL was made. Repeat bone marrow biopsy done 2 weeks after finishing chemotherapy revealed residual disease. At the 3-month follow-up, the patient was asymptomatic with a normocellular marrow and no residual disease. Repeat abdomen computerized tomography (CT) scan at completion of therapy showed resolution of duodenal thickening and spleen size of 12 cm. Currently, patient is in clinical remission for 6 years with 4-6 monthly follow-up visits and continues to do well. CONCLUSION: This case is presented to highlight the first case report of HCL with duodenal involvement that was successfully treated with CDA. |
format | Online Article Text |
id | pubmed-4488997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44889972015-07-21 Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report Sen, Parijat Shaaban, Hamid Modi, Tejas Kumar, Abhishek Guron, Gunwant N Am J Med Sci Case Report CONTEXT: A rare case of adult hairy cell leukemia (HCL) with duodenal involvement is presented. CASE REPORT: The patient was a 48-year-old man, who had a history of hairy cell leukemia. Three days after completion of 2-chlorodeoxyadenosine (CDA) chemotherapy, the patient started experiencing abdominal pain. An extensive gastroenterological workup culminated in the patient getting an esophagogastroduodenoscopy (EGD) that revealed duodenal inflammation and biopsies were taken. The duodenal biopsy was positive for chronic inflammatory infiltrate, primarily consisting of atypical lymphocytes and plasma cells with tartrate-resistant acid phosphatase (TRAP) positivity, and hence a diagnosis of duodenal involvement with HCL was made. Repeat bone marrow biopsy done 2 weeks after finishing chemotherapy revealed residual disease. At the 3-month follow-up, the patient was asymptomatic with a normocellular marrow and no residual disease. Repeat abdomen computerized tomography (CT) scan at completion of therapy showed resolution of duodenal thickening and spleen size of 12 cm. Currently, patient is in clinical remission for 6 years with 4-6 monthly follow-up visits and continues to do well. CONCLUSION: This case is presented to highlight the first case report of HCL with duodenal involvement that was successfully treated with CDA. Medknow Publications & Media Pvt Ltd 2015-06 /pmc/articles/PMC4488997/ /pubmed/26199927 http://dx.doi.org/10.4103/1947-2714.157489 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sen, Parijat Shaaban, Hamid Modi, Tejas Kumar, Abhishek Guron, Gunwant Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report |
title | Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report |
title_full | Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report |
title_fullStr | Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report |
title_full_unstemmed | Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report |
title_short | Hairy Cell Leukemia Presenting with Duodenal Involvement Duodenum: A Case Report |
title_sort | hairy cell leukemia presenting with duodenal involvement duodenum: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488997/ https://www.ncbi.nlm.nih.gov/pubmed/26199927 http://dx.doi.org/10.4103/1947-2714.157489 |
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