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Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis

CONTEXT: Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes. It is characterized by a triad of increased total body ketone concentration, metabolic acidosis, and uncontrolled hyperglycemia. Hyperglycemia is a key diagnostic criterion of DKA; however, in some rare cases,...

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Autores principales: Thawabi, Mohammad, Studyvin, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488998/
https://www.ncbi.nlm.nih.gov/pubmed/26199928
http://dx.doi.org/10.4103/1947-2714.157490
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author Thawabi, Mohammad
Studyvin, Sarah
author_facet Thawabi, Mohammad
Studyvin, Sarah
author_sort Thawabi, Mohammad
collection PubMed
description CONTEXT: Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes. It is characterized by a triad of increased total body ketone concentration, metabolic acidosis, and uncontrolled hyperglycemia. Hyperglycemia is a key diagnostic criterion of DKA; however, in some rare cases, normal glucose levels can be present. CASE REPORTS: We describe two patients with type 1 diabetes mellitus (DM1); one who presented with a Bartholin's gland abscess and the other with acute pancreatitis. Both patients had maintained adequate hydration and continued to take their insulin without sufficient carbohydrate intake in the previous days prior to presentation. Despite their normal serum glucose levels upon presentation, they were found to have ketonemia and acidosis consistent with DKA. If only the serum glucose level was taken into consideration, while ignoring the rest of their biochemical profiles and failing to obtain ketone levels, the diagnoses would have been missed. CONCLUSION: Euglycemic DKA is usually seen in otherwise healthy patients with type 1 diabetes mellitus who have decreased carbohydrate intake in the presence of adequate hydration and a degree of insulin intake. Recognition of this entity by the emergency provider is crucial when patients with DM1 present with a picture of DKA, regardless of their blood sugar.
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spelling pubmed-44889982015-07-21 Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis Thawabi, Mohammad Studyvin, Sarah N Am J Med Sci Case Report CONTEXT: Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes. It is characterized by a triad of increased total body ketone concentration, metabolic acidosis, and uncontrolled hyperglycemia. Hyperglycemia is a key diagnostic criterion of DKA; however, in some rare cases, normal glucose levels can be present. CASE REPORTS: We describe two patients with type 1 diabetes mellitus (DM1); one who presented with a Bartholin's gland abscess and the other with acute pancreatitis. Both patients had maintained adequate hydration and continued to take their insulin without sufficient carbohydrate intake in the previous days prior to presentation. Despite their normal serum glucose levels upon presentation, they were found to have ketonemia and acidosis consistent with DKA. If only the serum glucose level was taken into consideration, while ignoring the rest of their biochemical profiles and failing to obtain ketone levels, the diagnoses would have been missed. CONCLUSION: Euglycemic DKA is usually seen in otherwise healthy patients with type 1 diabetes mellitus who have decreased carbohydrate intake in the presence of adequate hydration and a degree of insulin intake. Recognition of this entity by the emergency provider is crucial when patients with DM1 present with a picture of DKA, regardless of their blood sugar. Medknow Publications & Media Pvt Ltd 2015-06 /pmc/articles/PMC4488998/ /pubmed/26199928 http://dx.doi.org/10.4103/1947-2714.157490 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Thawabi, Mohammad
Studyvin, Sarah
Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis
title Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis
title_full Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis
title_fullStr Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis
title_full_unstemmed Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis
title_short Euglycemic Diabetic Ketoacidosis, a Misleading Presentation of Diabetic Ketoacidosis
title_sort euglycemic diabetic ketoacidosis, a misleading presentation of diabetic ketoacidosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488998/
https://www.ncbi.nlm.nih.gov/pubmed/26199928
http://dx.doi.org/10.4103/1947-2714.157490
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