Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality

Viruses often encode proteins with multiple functions due to their compact genomes. Existing approaches to identify functional residues largely rely on sequence conservation analysis. Inferring functional residues from sequence conservation can produce false positives, in which the conserved residue...

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Detalles Bibliográficos
Autores principales: Wu, Nicholas C., Olson, C. Anders, Du, Yushen, Le, Shuai, Tran, Kevin, Remenyi, Roland, Gong, Danyang, Al-Mawsawi, Laith Q., Qi, Hangfei, Wu, Ting-Ting, Sun, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489113/
https://www.ncbi.nlm.nih.gov/pubmed/26132554
http://dx.doi.org/10.1371/journal.pgen.1005310

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