Cargando…
The roles of carboxylesterase and CYP isozymes on the in vitro metabolism of T-2 toxin
BACKGROUND: T-2 toxin poses a great threat to human health because it has the highest toxicity of the currently known trichothecene mycotoxins. To understand the in vivo toxicity and transformation mechanism of T-2 toxin, we investigated the role of one kind of principal phase I drug-metabolizing en...
Autores principales: | Lin, Ni-Ni, Chen, Jia, Xu, Bin, Wei, Xia, Guo, Lei, Xie, Jian-Wei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489217/ https://www.ncbi.nlm.nih.gov/pubmed/26140218 http://dx.doi.org/10.1186/s40779-015-0041-6 |
Ejemplares similares
-
Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs
por: Hosokawa, Masakiyo
Publicado: (2008) -
The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics
por: Di, Li
Publicado: (2018) -
Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity
por: Jia, Yumeng, et al.
Publicado: (2022) -
Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches
por: Sun, Jia, et al.
Publicado: (2017) -
Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro
por: Lin, Qian-Meng, et al.
Publicado: (2019)