Stock-based detection of protein oligomeric states in jsPISA

A new version of the popular software PISA for the analysis of macromolecular interfaces and identification of biological assemblies (complexes) from macromolecular crystal structures is presented. The new web server jsPISA has a substantially improved user interface, based on modern JavaScript tech...

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Detalles Bibliográficos
Autor principal: Krissinel, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Web Server issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489313/
https://www.ncbi.nlm.nih.gov/pubmed/25908787
http://dx.doi.org/10.1093/nar/gkv314
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author Krissinel, Eugene
author_facet Krissinel, Eugene
author_sort Krissinel, Eugene
collection PubMed
description A new version of the popular software PISA for the analysis of macromolecular interfaces and identification of biological assemblies (complexes) from macromolecular crystal structures is presented. The new web server jsPISA has a substantially improved user interface, based on modern JavaScript technologies, and also new elements of analysis: assembly stock and interaction radar. The new elements help interpretation of PISA results in difficult and ambiguous cases, for example, when the oligomeric state depends on protein concentration, or when the biologically relevant interaction is weak and cannot be easily discriminated from superficial crystal contacts. jsPISA is maintained by CCP4 at http://www.ccp4.ac.uk/pisa. There are no login requirements for using the server.
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spelling pubmed-44893132015-07-07 Stock-based detection of protein oligomeric states in jsPISA Krissinel, Eugene Nucleic Acids Res Web Server issue A new version of the popular software PISA for the analysis of macromolecular interfaces and identification of biological assemblies (complexes) from macromolecular crystal structures is presented. The new web server jsPISA has a substantially improved user interface, based on modern JavaScript technologies, and also new elements of analysis: assembly stock and interaction radar. The new elements help interpretation of PISA results in difficult and ambiguous cases, for example, when the oligomeric state depends on protein concentration, or when the biologically relevant interaction is weak and cannot be easily discriminated from superficial crystal contacts. jsPISA is maintained by CCP4 at http://www.ccp4.ac.uk/pisa. There are no login requirements for using the server. Oxford University Press 2015-07-01 2015-04-23 /pmc/articles/PMC4489313/ /pubmed/25908787 http://dx.doi.org/10.1093/nar/gkv314 Text en © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Web Server issue
Krissinel, Eugene
Stock-based detection of protein oligomeric states in jsPISA
title Stock-based detection of protein oligomeric states in jsPISA
title_full Stock-based detection of protein oligomeric states in jsPISA
title_fullStr Stock-based detection of protein oligomeric states in jsPISA
title_full_unstemmed Stock-based detection of protein oligomeric states in jsPISA
title_short Stock-based detection of protein oligomeric states in jsPISA
title_sort stock-based detection of protein oligomeric states in jspisa
topic Web Server issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489313/
https://www.ncbi.nlm.nih.gov/pubmed/25908787
http://dx.doi.org/10.1093/nar/gkv314
work_keys_str_mv AT krissineleugene stockbaseddetectionofproteinoligomericstatesinjspisa

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