Estimating Genome-Wide Significance for Whole-Genome Sequencing Studies

Although a standard genome-wide significance level has been accepted for the testing of association between common genetic variants and disease, the era of whole-genome sequencing (WGS) requires a new threshold. The allele frequency spectrum of sequence-identified variants is very different from com...

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Detalles Bibliográficos
Autores principales: Xu, ChangJiang, Tachmazidou, Ioanna, Walter, Klaudia, Ciampi, Antonio, Zeggini, Eleftheria, Greenwood, Celia M T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489336/
https://www.ncbi.nlm.nih.gov/pubmed/24676807
http://dx.doi.org/10.1002/gepi.21797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489336/
https://www.ncbi.nlm.nih.gov/pubmed/24676807
http://dx.doi.org/10.1002/gepi.21797

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