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Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment

To investigate the topological properties of the functional connectivity and their relationships with cognition impairment in subcortical vascular cognitive impairment (SVCI) patients, resting-state fMRI and graph theory approaches were employed in 23 SVCI patients and 20 healthy controls. Functiona...

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Detalles Bibliográficos
Autores principales: Yu, Yongqiang, Zhou, Xia, Wang, Haibao, Hu, Xiaopeng, Zhu, Xiaoqun, Xu, Liyan, Zhang, Chao, Sun, Zhongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489389/
https://www.ncbi.nlm.nih.gov/pubmed/26132397
http://dx.doi.org/10.1371/journal.pone.0131893
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author Yu, Yongqiang
Zhou, Xia
Wang, Haibao
Hu, Xiaopeng
Zhu, Xiaoqun
Xu, Liyan
Zhang, Chao
Sun, Zhongwu
author_facet Yu, Yongqiang
Zhou, Xia
Wang, Haibao
Hu, Xiaopeng
Zhu, Xiaoqun
Xu, Liyan
Zhang, Chao
Sun, Zhongwu
author_sort Yu, Yongqiang
collection PubMed
description To investigate the topological properties of the functional connectivity and their relationships with cognition impairment in subcortical vascular cognitive impairment (SVCI) patients, resting-state fMRI and graph theory approaches were employed in 23 SVCI patients and 20 healthy controls. Functional connectivity between 90 brain regions was estimated using bivariate correlation analysis and thresholded to construct a set of undirected graphs. Moreover, all of them were subjected to a battery of cognitive assessment, and the correlations between graph metrics and cognitive performance were further analyzed. Our results are as follows: functional brain networks of both SVCI patients and controls showed small-world attributes over a range of thresholds(0.15≤sparsity≤0.40). However, global topological organization of the functional brain networks in SVCI was significantly disrupted, as indicated by reduced global and local efficiency, clustering coefficients and increased characteristic path lengths relative to normal subjects. The decreased activity areas in SVCI predominantly targeted in the frontal-temporal lobes, while subcortical regions showed increased topological properties, which are suspected to compensate for the inefficiency of the functional network. We also demonstrated that altered brain network properties in SVCI are closely correlated with general cognitive and praxis dysfunction. The disruption of whole-brain topological organization of the functional connectome provides insight into the functional changes in the human brain in SVCI.
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spelling pubmed-44893892015-07-14 Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment Yu, Yongqiang Zhou, Xia Wang, Haibao Hu, Xiaopeng Zhu, Xiaoqun Xu, Liyan Zhang, Chao Sun, Zhongwu PLoS One Research Article To investigate the topological properties of the functional connectivity and their relationships with cognition impairment in subcortical vascular cognitive impairment (SVCI) patients, resting-state fMRI and graph theory approaches were employed in 23 SVCI patients and 20 healthy controls. Functional connectivity between 90 brain regions was estimated using bivariate correlation analysis and thresholded to construct a set of undirected graphs. Moreover, all of them were subjected to a battery of cognitive assessment, and the correlations between graph metrics and cognitive performance were further analyzed. Our results are as follows: functional brain networks of both SVCI patients and controls showed small-world attributes over a range of thresholds(0.15≤sparsity≤0.40). However, global topological organization of the functional brain networks in SVCI was significantly disrupted, as indicated by reduced global and local efficiency, clustering coefficients and increased characteristic path lengths relative to normal subjects. The decreased activity areas in SVCI predominantly targeted in the frontal-temporal lobes, while subcortical regions showed increased topological properties, which are suspected to compensate for the inefficiency of the functional network. We also demonstrated that altered brain network properties in SVCI are closely correlated with general cognitive and praxis dysfunction. The disruption of whole-brain topological organization of the functional connectome provides insight into the functional changes in the human brain in SVCI. Public Library of Science 2015-07-01 /pmc/articles/PMC4489389/ /pubmed/26132397 http://dx.doi.org/10.1371/journal.pone.0131893 Text en © 2015 Yu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yu, Yongqiang
Zhou, Xia
Wang, Haibao
Hu, Xiaopeng
Zhu, Xiaoqun
Xu, Liyan
Zhang, Chao
Sun, Zhongwu
Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment
title Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment
title_full Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment
title_fullStr Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment
title_full_unstemmed Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment
title_short Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment
title_sort small-world brain network and dynamic functional distribution in patients with subcortical vascular cognitive impairment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489389/
https://www.ncbi.nlm.nih.gov/pubmed/26132397
http://dx.doi.org/10.1371/journal.pone.0131893
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