A public health risk assessment for yellow fever vaccination: a model exemplified by an outbreak in the state of São Paulo, Brazil

We propose a method to analyse the 2009 outbreak in the region of Botucatu in the state of São Paulo (SP), Brazil, when 28 yellow fever (YF) cases were confirmed, including 11 deaths. At the time of the outbreak, the Secretary of Health of the State of São Paulo vaccinated one million people, causin...

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Detalles Bibliográficos
Autores principales: Ribeiro, Ana Freitas, Tengan, Ciléa, Sato, Helena Keico, Spinola, Roberta, Mascheretti, Melissa, França, Ana Cecilia Costa, Port-Carvalho, Marcio, Pereira, Mariza, de Souza, Renato Pereira, Amaku, Marcos, Burattini, Marcelo Nascimento, Coutinho, Francisco Antonio Bezerra, Lopez, Luis Fernandez, Massad, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489454/
https://www.ncbi.nlm.nih.gov/pubmed/25946247
http://dx.doi.org/10.1590/0074-02760140345
Descripción
Sumario:We propose a method to analyse the 2009 outbreak in the region of Botucatu in the state of São Paulo (SP), Brazil, when 28 yellow fever (YF) cases were confirmed, including 11 deaths. At the time of the outbreak, the Secretary of Health of the State of São Paulo vaccinated one million people, causing the death of five individuals, an unprecedented number of YF vaccine-induced fatalities. We apply a mathematical model described previously to optimise the proportion of people who should be vaccinated to minimise the total number of deaths. The model was used to calculate the optimum proportion that should be vaccinated in the remaining, vaccine-free regions of SP, considering the risk of vaccine-induced fatalities and the risk of YF outbreaks in these regions.

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