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Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis
Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB an...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489455/ https://www.ncbi.nlm.nih.gov/pubmed/25946248 http://dx.doi.org/10.1590/0074-02760140316 |
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author | Pedro, Heloisa da Silveira Paro Nardi, Susilene Maria Tonelli Pereira, Maria Izabel Ferreira Oliveira, Rosângela Siqueira Suffys, Philip Noel Gomes, Harrison Magdinier Finardi, Amanda Juliane de Moraes, Eloise Brasil Baptista, Ida Maria Foschiani Dias Machado, Ricardo Luiz Dantas Castiglioni, Lilian |
author_facet | Pedro, Heloisa da Silveira Paro Nardi, Susilene Maria Tonelli Pereira, Maria Izabel Ferreira Oliveira, Rosângela Siqueira Suffys, Philip Noel Gomes, Harrison Magdinier Finardi, Amanda Juliane de Moraes, Eloise Brasil Baptista, Ida Maria Foschiani Dias Machado, Ricardo Luiz Dantas Castiglioni, Lilian |
author_sort | Pedro, Heloisa da Silveira Paro |
collection | PubMed |
description | Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases. |
format | Online Article Text |
id | pubmed-4489455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-44894552015-07-06 Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis Pedro, Heloisa da Silveira Paro Nardi, Susilene Maria Tonelli Pereira, Maria Izabel Ferreira Oliveira, Rosângela Siqueira Suffys, Philip Noel Gomes, Harrison Magdinier Finardi, Amanda Juliane de Moraes, Eloise Brasil Baptista, Ida Maria Foschiani Dias Machado, Ricardo Luiz Dantas Castiglioni, Lilian Mem Inst Oswaldo Cruz Articles Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases. Instituto Oswaldo Cruz, Ministério da Saúde 2015-04 /pmc/articles/PMC4489455/ /pubmed/25946248 http://dx.doi.org/10.1590/0074-02760140316 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Pedro, Heloisa da Silveira Paro Nardi, Susilene Maria Tonelli Pereira, Maria Izabel Ferreira Oliveira, Rosângela Siqueira Suffys, Philip Noel Gomes, Harrison Magdinier Finardi, Amanda Juliane de Moraes, Eloise Brasil Baptista, Ida Maria Foschiani Dias Machado, Ricardo Luiz Dantas Castiglioni, Lilian Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
title | Clinical and epidemiological profiles of individuals with drug-resistant
tuberculosis |
title_full | Clinical and epidemiological profiles of individuals with drug-resistant
tuberculosis |
title_fullStr | Clinical and epidemiological profiles of individuals with drug-resistant
tuberculosis |
title_full_unstemmed | Clinical and epidemiological profiles of individuals with drug-resistant
tuberculosis |
title_short | Clinical and epidemiological profiles of individuals with drug-resistant
tuberculosis |
title_sort | clinical and epidemiological profiles of individuals with drug-resistant
tuberculosis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489455/ https://www.ncbi.nlm.nih.gov/pubmed/25946248 http://dx.doi.org/10.1590/0074-02760140316 |
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