T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children

We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein 3α, interleukin (IL)-17E and IL-17F in HAV-infected children with intermediat...

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Autores principales: Trujillo-Ochoa, Jorge L, Corral-Jara, Karla F, Escobedo-Meléndez, Griselda, Realpe, Mauricio, Panduro, Arturo, Roman, Sonia, Fierro, Nora A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489460/
https://www.ncbi.nlm.nih.gov/pubmed/25946253
http://dx.doi.org/10.1590/0074-02760140309
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author Trujillo-Ochoa, Jorge L
Corral-Jara, Karla F
Escobedo-Meléndez, Griselda
Realpe, Mauricio
Panduro, Arturo
Roman, Sonia
Fierro, Nora A
author_facet Trujillo-Ochoa, Jorge L
Corral-Jara, Karla F
Escobedo-Meléndez, Griselda
Realpe, Mauricio
Panduro, Arturo
Roman, Sonia
Fierro, Nora A
author_sort Trujillo-Ochoa, Jorge L
collection PubMed
description We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein 3α, interleukin (IL)-17E and IL-17F in HAV-infected children with intermediate liver injury compared with those with minor liver damage was found. A reduction in the IgE levels in those patients who showed the highest levels of IL-17F in the group of intermediate liver injury was found. The data suggested that the Th17-related profile is associated with the severity of HAV infection and might play a role on the modulation achieved by HAV during allergies.
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spelling pubmed-44894602015-07-06 T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children Trujillo-Ochoa, Jorge L Corral-Jara, Karla F Escobedo-Meléndez, Griselda Realpe, Mauricio Panduro, Arturo Roman, Sonia Fierro, Nora A Mem Inst Oswaldo Cruz Short Communication We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein 3α, interleukin (IL)-17E and IL-17F in HAV-infected children with intermediate liver injury compared with those with minor liver damage was found. A reduction in the IgE levels in those patients who showed the highest levels of IL-17F in the group of intermediate liver injury was found. The data suggested that the Th17-related profile is associated with the severity of HAV infection and might play a role on the modulation achieved by HAV during allergies. Instituto Oswaldo Cruz, Ministério da Saúde 2015-04 /pmc/articles/PMC4489460/ /pubmed/25946253 http://dx.doi.org/10.1590/0074-02760140309 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Trujillo-Ochoa, Jorge L
Corral-Jara, Karla F
Escobedo-Meléndez, Griselda
Realpe, Mauricio
Panduro, Arturo
Roman, Sonia
Fierro, Nora A
T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children
title T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children
title_full T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children
title_fullStr T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children
title_full_unstemmed T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children
title_short T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children
title_sort t-helper 17-related cytokines and ige antibodies during hepatitis a virus infection in children
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489460/
https://www.ncbi.nlm.nih.gov/pubmed/25946253
http://dx.doi.org/10.1590/0074-02760140309
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