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Congenital Chagas disease: an update

Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved fac...

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Autores principales: Carlier, Yves, Sosa-Estani, Sergio, Luquetti, Alejandro O, Buekens, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489473/
https://www.ncbi.nlm.nih.gov/pubmed/25760448
http://dx.doi.org/10.1590/0074-02760140405
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author Carlier, Yves
Sosa-Estani, Sergio
Luquetti, Alejandro O
Buekens, Pierre
author_facet Carlier, Yves
Sosa-Estani, Sergio
Luquetti, Alejandro O
Buekens, Pierre
author_sort Carlier, Yves
collection PubMed
description Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved factors, control strategy and possible prevention of congenital infection with T. cruzi. Considering that etiological treatment of the child is always effective if performed before one year of age, the diagnosis of infection in pregnant women and their newborns has to become the standard of care and integrated into the surveillance programs of syphilis and human immunodeficiency virus. In addition to the standard tests, polymerase chain reaction performed on blood of neonates of infected mothers one month after birth might improve the diagnosis of congenital infection. Recent data bring out that its transmission can be prevented through treatment of infected women before they become pregnant. The role of parasite genotypes and host genetic factors in parasite transmission and development of infection in foetuses/neonates has to be more investigated in order to better estimate the risk factors and impact on health of congenital infection with T. cruzi.
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spelling pubmed-44894732015-07-06 Congenital Chagas disease: an update Carlier, Yves Sosa-Estani, Sergio Luquetti, Alejandro O Buekens, Pierre Mem Inst Oswaldo Cruz Articles Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved factors, control strategy and possible prevention of congenital infection with T. cruzi. Considering that etiological treatment of the child is always effective if performed before one year of age, the diagnosis of infection in pregnant women and their newborns has to become the standard of care and integrated into the surveillance programs of syphilis and human immunodeficiency virus. In addition to the standard tests, polymerase chain reaction performed on blood of neonates of infected mothers one month after birth might improve the diagnosis of congenital infection. Recent data bring out that its transmission can be prevented through treatment of infected women before they become pregnant. The role of parasite genotypes and host genetic factors in parasite transmission and development of infection in foetuses/neonates has to be more investigated in order to better estimate the risk factors and impact on health of congenital infection with T. cruzi. Instituto Oswaldo Cruz, Ministério da Saúde 2015-05 /pmc/articles/PMC4489473/ /pubmed/25760448 http://dx.doi.org/10.1590/0074-02760140405 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Carlier, Yves
Sosa-Estani, Sergio
Luquetti, Alejandro O
Buekens, Pierre
Congenital Chagas disease: an update
title Congenital Chagas disease: an update
title_full Congenital Chagas disease: an update
title_fullStr Congenital Chagas disease: an update
title_full_unstemmed Congenital Chagas disease: an update
title_short Congenital Chagas disease: an update
title_sort congenital chagas disease: an update
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489473/
https://www.ncbi.nlm.nih.gov/pubmed/25760448
http://dx.doi.org/10.1590/0074-02760140405
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