Cargando…
Congenital Chagas disease: an update
Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved fac...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489473/ https://www.ncbi.nlm.nih.gov/pubmed/25760448 http://dx.doi.org/10.1590/0074-02760140405 |
_version_ | 1782379362618703872 |
---|---|
author | Carlier, Yves Sosa-Estani, Sergio Luquetti, Alejandro O Buekens, Pierre |
author_facet | Carlier, Yves Sosa-Estani, Sergio Luquetti, Alejandro O Buekens, Pierre |
author_sort | Carlier, Yves |
collection | PubMed |
description | Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved factors, control strategy and possible prevention of congenital infection with T. cruzi. Considering that etiological treatment of the child is always effective if performed before one year of age, the diagnosis of infection in pregnant women and their newborns has to become the standard of care and integrated into the surveillance programs of syphilis and human immunodeficiency virus. In addition to the standard tests, polymerase chain reaction performed on blood of neonates of infected mothers one month after birth might improve the diagnosis of congenital infection. Recent data bring out that its transmission can be prevented through treatment of infected women before they become pregnant. The role of parasite genotypes and host genetic factors in parasite transmission and development of infection in foetuses/neonates has to be more investigated in order to better estimate the risk factors and impact on health of congenital infection with T. cruzi. |
format | Online Article Text |
id | pubmed-4489473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-44894732015-07-06 Congenital Chagas disease: an update Carlier, Yves Sosa-Estani, Sergio Luquetti, Alejandro O Buekens, Pierre Mem Inst Oswaldo Cruz Articles Congenital infection with Trypanosoma cruzi is a global problem, occurring on average in 5% of children born from chronically infected mothers in endemic areas, with variations depending on the region. This presentation aims to focus on and update epidemiological data, research methods, involved factors, control strategy and possible prevention of congenital infection with T. cruzi. Considering that etiological treatment of the child is always effective if performed before one year of age, the diagnosis of infection in pregnant women and their newborns has to become the standard of care and integrated into the surveillance programs of syphilis and human immunodeficiency virus. In addition to the standard tests, polymerase chain reaction performed on blood of neonates of infected mothers one month after birth might improve the diagnosis of congenital infection. Recent data bring out that its transmission can be prevented through treatment of infected women before they become pregnant. The role of parasite genotypes and host genetic factors in parasite transmission and development of infection in foetuses/neonates has to be more investigated in order to better estimate the risk factors and impact on health of congenital infection with T. cruzi. Instituto Oswaldo Cruz, Ministério da Saúde 2015-05 /pmc/articles/PMC4489473/ /pubmed/25760448 http://dx.doi.org/10.1590/0074-02760140405 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Carlier, Yves Sosa-Estani, Sergio Luquetti, Alejandro O Buekens, Pierre Congenital Chagas disease: an update |
title | Congenital Chagas disease: an update |
title_full | Congenital Chagas disease: an update |
title_fullStr | Congenital Chagas disease: an update |
title_full_unstemmed | Congenital Chagas disease: an update |
title_short | Congenital Chagas disease: an update |
title_sort | congenital chagas disease: an update |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489473/ https://www.ncbi.nlm.nih.gov/pubmed/25760448 http://dx.doi.org/10.1590/0074-02760140405 |
work_keys_str_mv | AT carlieryves congenitalchagasdiseaseanupdate AT sosaestanisergio congenitalchagasdiseaseanupdate AT luquettialejandroo congenitalchagasdiseaseanupdate AT buekenspierre congenitalchagasdiseaseanupdate |