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Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A, promo...

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Detalles Bibliográficos
Autores principales:	Burgess, Selena G., Peset, Isabel, Joseph, Nimesh, Cavazza, Tommaso, Vernos, Isabelle, Pfuhl, Mark, Gergely, Fanni, Bayliss, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489650/ https://www.ncbi.nlm.nih.gov/pubmed/26134678 http://dx.doi.org/10.1371/journal.pgen.1005345

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