Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-...

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Detalles Bibliográficos
Autores principales: Evason, Kimberley J., Francisco, Macrina T., Juric, Vladislava, Balakrishnan, Sanjeev, Lopez Pazmino, Maria del Pilar, Gordan, John D., Kakar, Sanjay, Spitsbergen, Jan, Goga, Andrei, Stainier, Didier Y. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489858/
https://www.ncbi.nlm.nih.gov/pubmed/26134322
http://dx.doi.org/10.1371/journal.pgen.1005305

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