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An Epitope-Substituted DNA Vaccine Improves Safety and Immunogenicity against Dengue Virus Type 2
Dengue virus (DENV), a global disease, is divided into four serotypes (DENV1-4). Cross-reactive and non-neutralizing antibodies against envelope (E) protein of DENV bind to the Fcγ receptors (FcγR) of cells, and thereby exacerbate viral infection by heterologous serotypes via antibody-dependent enha...
Autores principales: | Tang, Chung-Tao, Li, Pi-Chun, Liu, I-Ju, Liao, Mei-Ying, Chiu, Chiung-Yi, Chao, Day-Yu, Wu, Han-Chung |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489899/ https://www.ncbi.nlm.nih.gov/pubmed/26135599 http://dx.doi.org/10.1371/journal.pntd.0003903 |
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