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Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells
T lymphocytes from many patients with systemic lupus erythematosus (SLE) express decreased levels of the T cell receptor (TCR)-associated CD3 zeta (ζ) signaling chain, a feature directly linked to their abnormal phenotype and function. Reduced mRNA expression partly due to defective alternative spli...
Autores principales: | Moulton, Vaishali R., Gillooly, Andrew R., Perl, Marcel A., Markopoulou, Anastasia, Tsokos, George C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489909/ https://www.ncbi.nlm.nih.gov/pubmed/26134847 http://dx.doi.org/10.1371/journal.pone.0131073 |
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